Fever of unknown origin in the hospitalized patient

Riddhi M. Shah, Caroline G. Castillo, Mary J. Burgess

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Fever of unknown origin (FUO) is defined as pyrexia of greater than 38.3°C for at least 3weeks with no identified cause after 3days of hospital evaluation or at least 3 outpatient visits. Infection, autoimmune disorders, and malignancy remain the most important causes of FUO in a hospitalized patient. Taking a complete history and performing a comprehensive physical examination are profoundly important in establishing the underlying cause of FUO, and imaging studies are becoming increasingly informative. Although the cause of FUO will remain undetermined in 20% of patients, these patients generally have a good prognosis.

Original languageEnglish (US)
Pages (from-to)e162-e172
JournalHospital Medicine Clinics
Issue number2
StatePublished - Apr 2014
Externally publishedYes


  • Differential diagnosis
  • Infection
  • Malignancy
  • Pyrexia
  • Vasculitis

ASJC Scopus subject areas

  • General Medicine


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