Fishing for a balance: Toward promyelinating drug discovery

Hannah Y. Collins, Ben Emery

Research output: Contribution to journalComment/debatepeer-review


In this issue, Häberlein et al. demonstrate a role for GPR17 in regulating zebrafish oligodendrocyte differentiation. Zebrafish expressing a humanized GPR17 respond to modulators, which are inactive against the endogenous zebrafish receptor. These findings highlight the potential for humanized zebrafish as an in vivo platform for targeted remyelination drug screens.

Original languageEnglish (US)
Pages (from-to)1467-1469
Number of pages3
JournalCell Chemical Biology
Issue number10
StatePublished - Oct 20 2022

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry


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