Five-year follow-up study of tardive dyskinesia.

G. Gardos; J. O. Cole; A. Perenyi; D. E. Casey; I. Samu; M. Kallos; S. Schniebolk

Five-year follow-up study of tardive dyskinesia.

G. Gardos, J. O. Cole, A. Perenyi, D. E. Casey, I. Samu, M. Kallos, S. Schniebolk

Research output: Contribution to journal › Article › peer-review

Abstract

A 5-year follow-up investigation of TD was carried out in 85 Hungarian schizophrenic out-patients. No substantial changes occurred during the 5 years in pharmacotherapy: most patients continued on neuroleptics and antiparkinson drugs. Comparison of 1978 and 1983 ratings revealed increased dyskinesia scores, which was statistically significant on the DRS Choreo-athetosis cluster. There was an increase in the number of patients with "moderately" severe TD from 4 in 1978 to 6 in 1981 to 10 (9 "Moderate" and 1 "Severe" TD) in 1983. The total number of TD cases as defined by research diagnostic criteria increased by only 3. The long-term trend in these neuroleptic-treated schizophrenics is for dyskinesia to plateau after reaching mild intensity, while in a minority of cases, the dyskinesia tends to extend from the oro-facial region to other body regions.

Original language	English (US)
Pages (from-to)	37-42
Number of pages	6
Journal	Advances in biochemical psychopharmacology
Volume	40
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

@article{a3ff82a5e049452f988aa851ab4f7987,

title = "Five-year follow-up study of tardive dyskinesia.",

abstract = "A 5-year follow-up investigation of TD was carried out in 85 Hungarian schizophrenic out-patients. No substantial changes occurred during the 5 years in pharmacotherapy: most patients continued on neuroleptics and antiparkinson drugs. Comparison of 1978 and 1983 ratings revealed increased dyskinesia scores, which was statistically significant on the DRS Choreo-athetosis cluster. There was an increase in the number of patients with {"}moderately{"} severe TD from 4 in 1978 to 6 in 1981 to 10 (9 {"}Moderate{"} and 1 {"}Severe{"} TD) in 1983. The total number of TD cases as defined by research diagnostic criteria increased by only 3. The long-term trend in these neuroleptic-treated schizophrenics is for dyskinesia to plateau after reaching mild intensity, while in a minority of cases, the dyskinesia tends to extend from the oro-facial region to other body regions.",

author = "G. Gardos and Cole, {J. O.} and A. Perenyi and Casey, {D. E.} and I. Samu and M. Kallos and S. Schniebolk",

note = "Funding Information: This work was supported by Ministry of Science and Technology of Zhejiang Province Grant 2018C03026; National Key Technologies R&D Program Grant 2014CB541704 from the Ministry of Science and Technology of China (to M. X. G.); National Natural Science Foundation of China Grants 81330024 (to M. X. G), 31671305, 81470685, and 81500804 (to S. S. G.); Nat-ural Science Foundation of Zhejiang Province, China, Grants LY18C060003 (to S. S. G.) and LY18C050002 (to X. H. C.); and Science and Technology Bureau of Taizhou City, Zhejiang Province, China, Grant 1901ky78 (to S. S. G.). The authors declare that they have no conflicts of interest with the contents of this article.",

year = "1985",

language = "English (US)",

volume = "40",

pages = "37--42",

journal = "Advances in biochemical psychopharmacology",

issn = "0065-2229",

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TY - JOUR

T1 - Five-year follow-up study of tardive dyskinesia.

AU - Gardos, G.

AU - Cole, J. O.

AU - Perenyi, A.

AU - Casey, D. E.

AU - Samu, I.

AU - Kallos, M.

AU - Schniebolk, S.

N1 - Funding Information: This work was supported by Ministry of Science and Technology of Zhejiang Province Grant 2018C03026; National Key Technologies R&D Program Grant 2014CB541704 from the Ministry of Science and Technology of China (to M. X. G.); National Natural Science Foundation of China Grants 81330024 (to M. X. G), 31671305, 81470685, and 81500804 (to S. S. G.); Nat-ural Science Foundation of Zhejiang Province, China, Grants LY18C060003 (to S. S. G.) and LY18C050002 (to X. H. C.); and Science and Technology Bureau of Taizhou City, Zhejiang Province, China, Grant 1901ky78 (to S. S. G.). The authors declare that they have no conflicts of interest with the contents of this article.

PY - 1985

Y1 - 1985

N2 - A 5-year follow-up investigation of TD was carried out in 85 Hungarian schizophrenic out-patients. No substantial changes occurred during the 5 years in pharmacotherapy: most patients continued on neuroleptics and antiparkinson drugs. Comparison of 1978 and 1983 ratings revealed increased dyskinesia scores, which was statistically significant on the DRS Choreo-athetosis cluster. There was an increase in the number of patients with "moderately" severe TD from 4 in 1978 to 6 in 1981 to 10 (9 "Moderate" and 1 "Severe" TD) in 1983. The total number of TD cases as defined by research diagnostic criteria increased by only 3. The long-term trend in these neuroleptic-treated schizophrenics is for dyskinesia to plateau after reaching mild intensity, while in a minority of cases, the dyskinesia tends to extend from the oro-facial region to other body regions.

AB - A 5-year follow-up investigation of TD was carried out in 85 Hungarian schizophrenic out-patients. No substantial changes occurred during the 5 years in pharmacotherapy: most patients continued on neuroleptics and antiparkinson drugs. Comparison of 1978 and 1983 ratings revealed increased dyskinesia scores, which was statistically significant on the DRS Choreo-athetosis cluster. There was an increase in the number of patients with "moderately" severe TD from 4 in 1978 to 6 in 1981 to 10 (9 "Moderate" and 1 "Severe" TD) in 1983. The total number of TD cases as defined by research diagnostic criteria increased by only 3. The long-term trend in these neuroleptic-treated schizophrenics is for dyskinesia to plateau after reaching mild intensity, while in a minority of cases, the dyskinesia tends to extend from the oro-facial region to other body regions.

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Five-year follow-up study of tardive dyskinesia.

Abstract

ASJC Scopus subject areas

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