Flexible, scalable, high channel count stereo-electrode for recording in the human brain

Keundong Lee; Angelique C. Paulk; Yun Goo Ro; Daniel R. Cleary; Karen J. Tonsfeldt; Yoav Kfir; John S. Pezaris; Youngbin Tchoe; Jihwan Lee; Andrew M. Bourhis; Ritwik Vatsyayan; Joel R. Martin; Samantha M. Russman; Jimmy C. Yang; Amy Baohan; R. Mark Richardson; Ziv M. Williams; Shelley I. Fried; U. Hoi Sang; Ahmed M. Raslan; Sharona Ben-Haim; Eric Halgren; Sydney S. Cash; Shadi A. Dayeh

doi:10.1038/s41467-023-43727-9

Flexible, scalable, high channel count stereo-electrode for recording in the human brain

Keundong Lee, Angelique C. Paulk, Yun Goo Ro, Daniel R. Cleary, Karen J. Tonsfeldt, Yoav Kfir, John S. Pezaris, Youngbin Tchoe, Jihwan Lee, Andrew M. Bourhis, Ritwik Vatsyayan, Joel R. Martin, Samantha M. Russman, Jimmy C. Yang, Amy Baohan, R. Mark Richardson, Ziv M. Williams, Shelley I. Fried, U. Hoi Sang, Ahmed M. RaslanSharona Ben-Haim, Eric Halgren, Sydney S. Cash, Shadi A. Dayeh

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Over the past decade, stereotactically placed electrodes have become the gold standard for deep brain recording and stimulation for a wide variety of neurological and psychiatric diseases. Current electrodes, however, are limited in their spatial resolution and ability to record from small populations of neurons, let alone individual neurons. Here, we report on an innovative, customizable, monolithically integrated human-grade flexible depth electrode capable of recording from up to 128 channels and able to record at a depth of 10 cm in brain tissue. This thin, stylet-guided depth electrode is capable of recording local field potentials and single unit neuronal activity (action potentials), validated across species. This device represents an advance in manufacturing and design approaches which extends the capabilities of a mainstay technology in clinical neurology.

Original language	English (US)
Article number	218
Journal	Nature communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-023-43727-9
State	Published - Dec 2024

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/s41467-023-43727-9

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Lee, K., Paulk, A. C., Ro, Y. G., Cleary, D. R., Tonsfeldt, K. J., Kfir, Y., Pezaris, J. S., Tchoe, Y., Lee, J., Bourhis, A. M., Vatsyayan, R., Martin, J. R., Russman, S. M., Yang, J. C., Baohan, A., Richardson, R. M., Williams, Z. M., Fried, S. I., Hoi Sang, U., ... Dayeh, S. A. (2024). Flexible, scalable, high channel count stereo-electrode for recording in the human brain. Nature communications, 15(1), Article 218. https://doi.org/10.1038/s41467-023-43727-9

Lee, K, Paulk, AC, Ro, YG, Cleary, DR, Tonsfeldt, KJ, Kfir, Y, Pezaris, JS, Tchoe, Y, Lee, J, Bourhis, AM, Vatsyayan, R, Martin, JR, Russman, SM, Yang, JC, Baohan, A, Richardson, RM, Williams, ZM, Fried, SI, Hoi Sang, U, Raslan, AM, Ben-Haim, S, Halgren, E, Cash, SS & Dayeh, SA 2024, 'Flexible, scalable, high channel count stereo-electrode for recording in the human brain', Nature communications, vol. 15, no. 1, 218. https://doi.org/10.1038/s41467-023-43727-9

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abstract = "Over the past decade, stereotactically placed electrodes have become the gold standard for deep brain recording and stimulation for a wide variety of neurological and psychiatric diseases. Current electrodes, however, are limited in their spatial resolution and ability to record from small populations of neurons, let alone individual neurons. Here, we report on an innovative, customizable, monolithically integrated human-grade flexible depth electrode capable of recording from up to 128 channels and able to record at a depth of 10 cm in brain tissue. This thin, stylet-guided depth electrode is capable of recording local field potentials and single unit neuronal activity (action potentials), validated across species. This device represents an advance in manufacturing and design approaches which extends the capabilities of a mainstay technology in clinical neurology.",

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AU - Kfir, Yoav

AU - Pezaris, John S.

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AU - Lee, Jihwan

AU - Bourhis, Andrew M.

AU - Vatsyayan, Ritwik

AU - Martin, Joel R.

AU - Russman, Samantha M.

AU - Yang, Jimmy C.

AU - Baohan, Amy

AU - Richardson, R. Mark

AU - Williams, Ziv M.

AU - Fried, Shelley I.

AU - Hoi Sang, U.

AU - Raslan, Ahmed M.

AU - Ben-Haim, Sharona

AU - Halgren, Eric

AU - Cash, Sydney S.

AU - Dayeh, Shadi A.

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Flexible, scalable, high channel count stereo-electrode for recording in the human brain

Abstract

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