Fluoride selenium interaction in the hard and soft tissues of the rat

T. R. Shearer, J. W. Ridlington

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The interaction of dietary fluoride and selenium in the hard and soft tissues of rats was studied by providing drinking solutions containing 50 ppm F, as NaF, alone or plus 1 or 3 ppm Se as one of the following selenium compounds: NaSeO3, Na2SeO4, DL selenomethionine, or DL selenocystine. The following parameters were measured: symptoms of selenium toxicity, soft tissue uptake of fluoride and selenium, histology of liver and kidney tissues, fluoride uptake into growing femur bones, and fluoride uptake onto calcified molar enamel. No evidence was found that fluoride interacted with any of the four selenium compounds.

Original languageEnglish (US)
Pages (from-to)451-456
Number of pages6
JournalJournal of Nutrition
Issue number4
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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