Fluphenazine activity and antipsychotic response

Robert J. Hitzemann, David L. Garver, Michael Mavroidis, Jack Hirschowitz, Frank P. Zemlan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Plasma fluphenazine levels and plasma total neuroleptic activity (as quantitated by the neuroleptic receptor binding assay) were related to therapeutic response in 15 DSM-III schizophrenic patients who received a predetermined, fixed dose of fluphenazine for 14 days. Mean neuroleptic activity of the plasma was 84% greater than can be accounted for by the parent fluphenazine alone, and varied widely between patients. A sigmoidal relationship between total neuroleptic activity of plasma and response was found, with a continued plateau of response at higher total neuroleptic levels. Furthermore, the RBA data suggested (P<0.002) that two populations of drug-responsive schizophrenics exist which may be discriminated by the total D2 binding activity of plasma required for response.

Original languageEnglish (US)
Pages (from-to)270-273
Number of pages4
Issue number2
StatePublished - Sep 1986
Externally publishedYes


  • Antipsychotic drug
  • Drug level-response
  • Drug response
  • Fluphenazine
  • Gas chromatography
  • Radioreceptor binding assay
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology


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