Folding Biology of Cystic Fibrosis: A Consortium-Based Approach to Disease

William E. Balch, Ineke Braakman, Jeff Brodsky, Raymond Frizzell, William Guggino, Gergely L. Lukacs, Christopher Penland, Harvey Pollard, William Skach, Eric Sorscher, Philip Thomas

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
Original languageEnglish (US)
Title of host publicationProtein Misfolding Diseases
Subtitle of host publicationCurrent and Emerging Principles and Therapies
PublisherJohn Wiley and Sons
Number of pages28
ISBN (Print)9780471799283
StatePublished - Jul 2 2010
Externally publishedYes


  • CFTR folding, series of sequential steps - nascent polypeptide, targeted to endoplasmic reticulum (ER)
  • Cystic fibrosis folding biology - consortium-based approach to disease
  • Trafficking to cell surface - "minimal export threshold" embracing key fundamental properties of protein fold-folding kinetics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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