Frozen Red Blood Cells

Yuxuan Wang; Martin A. Schreiber

doi:10.1007/978-3-030-20820-2_10

Frozen Red Blood Cells

Yuxuan Wang, Martin A. Schreiber

Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Cryopreservation of red blood cells (RBCs) is performed by the addition of glycerol and can be frozen for up to 37 years. Prior to use, they must be thawed and the glycerol removed. Interest in frozen RBCs reached its height in the 1960s and 1970s due to the 21-day shelf life of liquid RBCs, as they proved to be a viable alternative to liquid RBCs in the event of emergencies, have less hepatitis infections, and was useful in the preservation of rare blood types. Clinical studies have shown frozen RBCs to have less pro-inflammatory molecules. Enthusiasm in frozen RBCs began to dwindle after the doubling of liquid RBC storage time to 42 days and improved screening of donor blood. However, frozen RBCs still play an important role for rare blood storage and as a backup in times of emergencies.

Original language	English (US)
Title of host publication	Damage Control Resuscitation
Subtitle of host publication	Identification and Treatment of Life-Threatening Hemorrhage
Publisher	Springer International Publishing
Pages	185-196
Number of pages	12
ISBN (Electronic)	9783030208202
ISBN (Print)	9783030208196
DOIs	https://doi.org/10.1007/978-3-030-20820-2_10
State	Published - Jan 1 2019

Keywords

Blood bank
Blood transfusions
Cryopreservation
Disaster management
Frozen red blood cells
Glycerolization
Rare blood
Red blood cell storage lesion
Resuscitation
Trauma

ASJC Scopus subject areas

General Medicine
General Health Professions

Access to Document

10.1007/978-3-030-20820-2_10

Cite this

@inbook{d115b9ac56024181aa4c0508cb16c938,

title = "Frozen Red Blood Cells",

abstract = "Cryopreservation of red blood cells (RBCs) is performed by the addition of glycerol and can be frozen for up to 37 years. Prior to use, they must be thawed and the glycerol removed. Interest in frozen RBCs reached its height in the 1960s and 1970s due to the 21-day shelf life of liquid RBCs, as they proved to be a viable alternative to liquid RBCs in the event of emergencies, have less hepatitis infections, and was useful in the preservation of rare blood types. Clinical studies have shown frozen RBCs to have less pro-inflammatory molecules. Enthusiasm in frozen RBCs began to dwindle after the doubling of liquid RBC storage time to 42 days and improved screening of donor blood. However, frozen RBCs still play an important role for rare blood storage and as a backup in times of emergencies.",

keywords = "Blood bank, Blood transfusions, Cryopreservation, Disaster management, Frozen red blood cells, Glycerolization, Rare blood, Red blood cell storage lesion, Resuscitation, Trauma",

author = "Yuxuan Wang and Schreiber, {Martin A.}",

note = "Publisher Copyright: {\textcopyright} Springer Nature Switzerland AG 2020.",

year = "2019",

month = jan,

day = "1",

doi = "10.1007/978-3-030-20820-2_10",

language = "English (US)",

isbn = "9783030208196",

pages = "185--196",

booktitle = "Damage Control Resuscitation",

publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Frozen Red Blood Cells

AU - Wang, Yuxuan

AU - Schreiber, Martin A.

N1 - Publisher Copyright: © Springer Nature Switzerland AG 2020.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Cryopreservation of red blood cells (RBCs) is performed by the addition of glycerol and can be frozen for up to 37 years. Prior to use, they must be thawed and the glycerol removed. Interest in frozen RBCs reached its height in the 1960s and 1970s due to the 21-day shelf life of liquid RBCs, as they proved to be a viable alternative to liquid RBCs in the event of emergencies, have less hepatitis infections, and was useful in the preservation of rare blood types. Clinical studies have shown frozen RBCs to have less pro-inflammatory molecules. Enthusiasm in frozen RBCs began to dwindle after the doubling of liquid RBC storage time to 42 days and improved screening of donor blood. However, frozen RBCs still play an important role for rare blood storage and as a backup in times of emergencies.

AB - Cryopreservation of red blood cells (RBCs) is performed by the addition of glycerol and can be frozen for up to 37 years. Prior to use, they must be thawed and the glycerol removed. Interest in frozen RBCs reached its height in the 1960s and 1970s due to the 21-day shelf life of liquid RBCs, as they proved to be a viable alternative to liquid RBCs in the event of emergencies, have less hepatitis infections, and was useful in the preservation of rare blood types. Clinical studies have shown frozen RBCs to have less pro-inflammatory molecules. Enthusiasm in frozen RBCs began to dwindle after the doubling of liquid RBC storage time to 42 days and improved screening of donor blood. However, frozen RBCs still play an important role for rare blood storage and as a backup in times of emergencies.

KW - Blood bank

KW - Blood transfusions

KW - Cryopreservation

KW - Disaster management

KW - Frozen red blood cells

KW - Glycerolization

KW - Rare blood

KW - Red blood cell storage lesion

KW - Resuscitation

KW - Trauma

UR - http://www.scopus.com/inward/record.url?scp=85148784565&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85148784565&partnerID=8YFLogxK

U2 - 10.1007/978-3-030-20820-2_10

DO - 10.1007/978-3-030-20820-2_10

M3 - Chapter

AN - SCOPUS:85148784565

SN - 9783030208196

SP - 185

EP - 196

BT - Damage Control Resuscitation

PB - Springer International Publishing

ER -

Frozen Red Blood Cells

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this