Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder

Fei Wang, Jessica H. Kalmar, Yong He, Marcel Jackowski, Lara G. Chepenik, Elliot Kale Edmiston, Karen Tie, Gaolang Gong, Maulik P. Shah, Monique Jones, Jodi Uderman, R. Todd Constable, Hilary P. Blumberg

Research output: Contribution to journalArticlepeer-review

179 Scopus citations


Objective: Abnormalities in the morphology and function of two gray matter structures central to emotional processing, the perigenual anterior cingulate cortex (pACC) and amygdala, have consistently been reported in bipolar disorder (BD). Evidence implicates abnormalities in their connectivity in BD. This study investigates the potential disruptions in pACC-amygdala functional connectivity and associated abnormalities in white matter that provides structural connections between the two brain regions in BD. Methods: Thirty-three individuals with BD and 31 healthy comparison subjects (HC) participated in a scanning session during which functional magnetic resonance imaging (fMRI) during processing of face stimuli and diffusion tensor imaging (DTI) were performed. The strength of pACC-amygdala functional connections was compared between BD and HC groups, and associations between these functional connectivity measures from the fMRI scans and regional fractional anisotropy (FA) from the DTI scans were assessed. Results: Functional connectivity was decreased between the pACC and amygdala in the BD group compared with HC group, during the processing of fearful and happy faces (p < .005). Moreover, a significant positive association between pACC-amygdala functional coupling and FA in ventrofrontal white matter, including the region of the uncinate fasciculus, was identified (p < .005). Conclusion: This study provides evidence for abnormalities in pACC-amygdala functional connectivity during emotional processing in BD. The significant association between pACC-amygdala functional connectivity and the structural integrity of white matter that contains pACC-amygdala connections suggest that disruptions in white matter connectivity may contribute to disturbances in the coordinated responses of the pACC and amygdala during emotional processing in BD.

Original languageEnglish (US)
Pages (from-to)516-521
Number of pages6
JournalBiological Psychiatry
Issue number5
StatePublished - Sep 1 2009
Externally publishedYes


  • Amygdala
  • anterior cingulate cortex
  • bipolar disorder
  • diffusion tensor imaging
  • fMRI
  • functional connectivity
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Biological Psychiatry


Dive into the research topics of 'Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder'. Together they form a unique fingerprint.

Cite this