TY - JOUR
T1 - Functional neuroanatomy of aversion and its anticipation
AU - Nitschke, Jack B.
AU - Sarinopoulos, Issidoros
AU - MacKiewicz, Kristen L.
AU - Schaefer, Hillary S.
AU - Davidson, Richard J.
N1 - Funding Information:
We gratefully acknowledge Michael Anderle, Krystal Cleven, Kelli Ferber, Tom Johnstone, Hyejeen Lee, Terrence Oakes, Adrian Pederson, Alissa Possin, Thomas Ihde-Scholl, Brian Skinner, and Lesley Tarleton for their contributions to this project. JBN was supported by an NIMH Career Development Award (K08-MH63984), a Training Program in Emotion Research NIMH grant (T32-MH18931), and a Health Emotions Research Institute fellowship. RJD was supported by NIMH grants (MH40747, P50-MH52354, MH43454) and an NIMH Research Scientist Award (K05-MH00875). The research reported in this publication was also supported by a core grant to the Waisman Center from the National Institute of Child Health and Human Development (P30 HD03352). Parts of this work were presented at the 10th annual meeting of the Organization for Human Brain Mapping in Budapest, Hungary, June, 2004.
PY - 2006/1/1
Y1 - 2006/1/1
N2 - The capacity to anticipate aversive circumstances is central not only to successful adaptation but also to understanding the abnormalities that contribute to excessive worry and anxiety disorders. Forecasting and reacting to aversive events mobilize a host of affective and cognitive capacities and corresponding brain processes. Rapid event-related functional magnetic resonance imaging (fMRI) in 21 healthy volunteers assessed the overlap and divergence in the neural instantiation of anticipating and being exposed to aversive pictures. Brain areas jointly activated by the anticipation of and exposure to aversive pictures included the dorsal amygdala, anterior insula, dorsal anterior cingulate cortex (ACC), right dorsolateral prefrontal cortex (DLPFC), and right posterior orbitofrontal cortex (OFC). Anticipatory processes were uniquely associated with activations in rostral ACC, a more superior sector of the right DLPFC, and more medial sectors of the bilateral OFC. Activation of the right DLPFC in anticipation of aversion was associated with self-reports of increased negative affect, whereas OFC activation was associated with increases in both positive and negative affect. These results show that anticipation of aversion recruits key brain regions that respond to aversion, thereby potentially enhancing adaptive responses to aversive events.
AB - The capacity to anticipate aversive circumstances is central not only to successful adaptation but also to understanding the abnormalities that contribute to excessive worry and anxiety disorders. Forecasting and reacting to aversive events mobilize a host of affective and cognitive capacities and corresponding brain processes. Rapid event-related functional magnetic resonance imaging (fMRI) in 21 healthy volunteers assessed the overlap and divergence in the neural instantiation of anticipating and being exposed to aversive pictures. Brain areas jointly activated by the anticipation of and exposure to aversive pictures included the dorsal amygdala, anterior insula, dorsal anterior cingulate cortex (ACC), right dorsolateral prefrontal cortex (DLPFC), and right posterior orbitofrontal cortex (OFC). Anticipatory processes were uniquely associated with activations in rostral ACC, a more superior sector of the right DLPFC, and more medial sectors of the bilateral OFC. Activation of the right DLPFC in anticipation of aversion was associated with self-reports of increased negative affect, whereas OFC activation was associated with increases in both positive and negative affect. These results show that anticipation of aversion recruits key brain regions that respond to aversion, thereby potentially enhancing adaptive responses to aversive events.
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U2 - 10.1016/j.neuroimage.2005.06.068
DO - 10.1016/j.neuroimage.2005.06.068
M3 - Article
C2 - 16181793
AN - SCOPUS:29244491633
SN - 1053-8119
VL - 29
SP - 106
EP - 116
JO - NeuroImage
JF - NeuroImage
IS - 1
ER -