Furosemide pharmacokinetics following intratracheal instillation in the guinea pig

S. A. Smith, D. A.M. Pillers, J. T. Gilhooly, M. A. Wall, G. D. Olsen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Inhaled furosemide has been shown to attenuate bronchospasm in asthmatics and to increase lung compliance in infants with bronchopulmonary dysplasia (BPD). The reports involving BPD used a dose of 1 mg/kg and some have failed to show an effect with that dose. We determined the pharmacokinetics of furosemide administered directly to the airway in 7 young adult male guinea pigs who received intravenous and intratracheal doses of furosemide. Each animal received a 3 mg/kg i.v. bolus, 1, 3 and 6 mg/kg i.t. in 2 ml/kg normal saline and 3 mg/kg i.t. in 2 ml/kg bovine extract surfactant. Blood was sampled multiple times after each dose. The mean fraction of the intratracheal dose absorbed was 0.50-0.60 for all doses. Surfactant delayed the absorption of furosemide but did not alter the fraction absorbed.

Original languageEnglish (US)
Pages (from-to)191-199
Number of pages9
JournalBiology of the Neonate
Issue number3
StatePublished - 1995
Externally publishedYes


  • Furosemide, inhaled
  • Guinea pig
  • Intratracheal instillation
  • Pharmacokinetics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology


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