G-Protein-Coupled Receptor SRBC-48 Protects against Dendrite Degeneration and Reduced Longevity Due to Infection

Supender Kaur, Alejandro Aballay

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Increasing evidence suggests that deficient immune modulation and microbial infections underline neurodegeneration, but the mechanisms remain obscure. Here, we show that the G-protein-coupled receptor (GPCR) SRBC-48, which belongs to the class BC serpentine receptors, has a protective role in Caenorhabditis elegans dendrite degeneration caused by Pseudomonas aeruginosa infection. Our results indicate that SRBC-48 functions in a cell-autonomous manner in AWC neurons to protect against infection-associated dendrite degeneration. The absence of SRBC-48 results in a reduced lifespan caused by a pathogen infection early in life that induces dendrite degeneration. The decreased longevity in animals deficient in SRBC-48 is due to uncontrolled activation of immune genes, particularly those regulated by the FOXO family transcription factor DAF-16 that is part of the insulin/insulin-like growth factor (IGF)-1 receptor homolog DAF-2. These results reveal how an infection early in life can not only induce dendrite degeneration but also reduce lifespan.

Original languageEnglish (US)
Article number107662
JournalCell Reports
Issue number7
StatePublished - May 19 2020


  • Caenorhabditis elegans
  • DAF-16
  • G-protein-coupled receptor
  • Pseudomonas aeruginosa
  • SRBC-48
  • infection
  • inflammation
  • longevity
  • neurodegeneration
  • pathogens

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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