Gadolinium DTPA enhanced MR imaging of acth-secreting microadenomas of the pituitary gland

John L. Doppman, Joseph A. Frank, Andrew J. Dwyer, Edward H. Oldfield, Donald L. Miller, Lynnette K. Nieman, George P. Chrousos, Gordon B. Cutler, D. Lynn Loriaux

Research output: Contribution to journalArticlepeer-review

125 Scopus citations


Gadolinium diethylenetriamine pentaacetic acid (DTPA) enhanced magnetic resonance imaging was performed in eight patients with Cushing disease and surgically proven pituitary microadenomas. A 1.5 T scanner was used with 3 mm contiguous slices. Short repetition times (TR), short echo times (TE), and long TR, long TE sequences were obtained before and serially after intravenous administration of Gd-DTPA. Three of eight (38%) microadenomas were undetectable both without and with Gd-DTPA: one post-Gd-DTPA scan was false positive on the side opposite the adenoma. Hemihy-pophysectomy based on a petrosal sinus adrenocorticotropic hormone (ACTH) gradient cured all three patients. Two microadenomas (25%) were visible as hypointense foci following Gd-DTPA but not on unenhanced scans. The remaining three microadenomas (38%) were seen before and after Gd-DTPA on Tl-weighted images. In this small series of ACTH-producing microadenomas, one-third were seen on unenhanced 1.5 T scans, one-third were seen only after Gd-DTPA, and one-third were not imaged even with Gd-DTPA enhancement.

Original languageEnglish (US)
Pages (from-to)728-735
Number of pages8
JournalJournal of Computer Assisted Tomography
Issue number5
StatePublished - Sep 1988
Externally publishedYes


  • ACTH
  • Contrast medium
  • Magnetic resonance imaging
  • Neoplasms
  • Pituitary gland

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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