Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons

Hidehiko Shogomori, Michelle A. Burack, Gary Banker, Anthony H. Futerman

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Analysis of the binding of cholera toxin to ganglioside GM1 in both living and fixed neurons, and comparison with the distribution of defined axonal and dendritic proteins, demonstrates that ganglioside GM1 is distributed in a non-polarized manner over the axonal and dendritic plasma membranes of mature, cultured hippocampal neurons. Likewise, ganglioside GD1b is also distributed in a non-polarized manner. These results suggest that a recent report [Ledesma, M.D. et al. EMBO J. 18 (1999) 1761-1771] proposing that ganglioside GM1 is highly enriched on the axonal versus dendritic membrane of hippocampal neurons may need to be re-evaluated. Copyright (C) 1999 Federation of European Biochemical Societies.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalFEBS Letters
Issue number2
StatePublished - Sep 17 1999
Externally publishedYes


  • Axon
  • Cholera toxin
  • Dendrite
  • Ganglioside
  • Neuron
  • Polarity

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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