TY - JOUR
T1 - Gastrointestinal Manifestations of Coronavirus Disease 2019 Across the United States
T2 - A Multicenter Cohort Study
AU - Patel, Ankur P.
AU - Sanders, Troy K.
AU - Prakash, Preeti
AU - Law, Jade
AU - Alvencar, Sujay
AU - Choi, Alyssa
AU - Shah, Janaki
AU - Patel, Karishma
AU - Srivoleti, Padmavathi
AU - Chauhan, Kirtan
AU - Weissman, Simcha
AU - Holzwanger, Erik
AU - Dhingra, Rohit
AU - Nguyen, Michelle
AU - Kim, Daniel
AU - Sidhu, Tahnee
AU - Stallwood, Christopher
AU - Dickstein, Aaron
AU - Parekh, Nimisha
AU - Altayar, Osama
AU - Ciorba, Matthew A.
AU - Yu, Jessica
AU - Chen, Lea Ann
AU - Tabibian, James H.
AU - Limketkai, Berkeley N.
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/1
Y1 - 2022/1
N2 - Background and Aims: Gastrointestinal (GI) symptoms occur among patients diagnosed with coronavirus disease 2019 (COVID-19), and there is clear evidence that SARS-CoV-2, the causative pathogen, infects the GI tract. In this large, multicenter cohort study, we evaluated variations in gastrointestinal and hepatic manifestations of COVID-19 throughout the United States (US). Methods: Patients hospitalized with a positive COVID-19 test prior to October 2020 were identified at 7 US academic centers. Demographics, presenting symptoms, laboratory data, and hospitalization outcomes were abstracted. Descriptive and regression analyses were used to evaluate GI manifestations and their potential predictors. Results: Among 2031 hospitalized patients with COVID-19, GI symptoms were present in 18.9%; diarrhea was the most common (15.2%), followed by nausea and/or vomiting (12.6%) and abdominal pain (6.0%). GI symptoms were less common in the Western cohort (16.0%) than the Northeastern (25.6%) and Midwestern (26.7%) cohorts. Compared to nonintensive care unit (ICU) patients, ICU patients had a higher prevalence of abnormal aspartate aminotransferase (58.1% vs 37.3%; P <.01), alanine aminotransferase (37.5% vs 29.3%; P =.01), and total bilirubin (12.7% vs 9.0%; P <.01). ICU patients also had a higher mortality rate (22.7% vs 4.7%; P <.01). Chronic liver disease was associated with the development of GI symptoms. Abnormal aspartate aminotransferase or alanine aminotransferase was associated with an increased risk of ICU admission. Conclusion: We present the largest multicenter cohort of patients with COVID-19 across the United States. GI manifestations were common among patients hospitalized with COVID-19, although there was significant variability in prevalence and predictors across the United States.
AB - Background and Aims: Gastrointestinal (GI) symptoms occur among patients diagnosed with coronavirus disease 2019 (COVID-19), and there is clear evidence that SARS-CoV-2, the causative pathogen, infects the GI tract. In this large, multicenter cohort study, we evaluated variations in gastrointestinal and hepatic manifestations of COVID-19 throughout the United States (US). Methods: Patients hospitalized with a positive COVID-19 test prior to October 2020 were identified at 7 US academic centers. Demographics, presenting symptoms, laboratory data, and hospitalization outcomes were abstracted. Descriptive and regression analyses were used to evaluate GI manifestations and their potential predictors. Results: Among 2031 hospitalized patients with COVID-19, GI symptoms were present in 18.9%; diarrhea was the most common (15.2%), followed by nausea and/or vomiting (12.6%) and abdominal pain (6.0%). GI symptoms were less common in the Western cohort (16.0%) than the Northeastern (25.6%) and Midwestern (26.7%) cohorts. Compared to nonintensive care unit (ICU) patients, ICU patients had a higher prevalence of abnormal aspartate aminotransferase (58.1% vs 37.3%; P <.01), alanine aminotransferase (37.5% vs 29.3%; P =.01), and total bilirubin (12.7% vs 9.0%; P <.01). ICU patients also had a higher mortality rate (22.7% vs 4.7%; P <.01). Chronic liver disease was associated with the development of GI symptoms. Abnormal aspartate aminotransferase or alanine aminotransferase was associated with an increased risk of ICU admission. Conclusion: We present the largest multicenter cohort of patients with COVID-19 across the United States. GI manifestations were common among patients hospitalized with COVID-19, although there was significant variability in prevalence and predictors across the United States.
KW - COVID-19
KW - Coronavirus Disease 2019
KW - Gastrointestinal
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85138617933&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85138617933&partnerID=8YFLogxK
U2 - 10.1016/j.gastha.2022.07.002
DO - 10.1016/j.gastha.2022.07.002
M3 - Article
AN - SCOPUS:85138617933
SN - 2772-5723
VL - 1
SP - 909
EP - 915
JO - Gastro Hep Advances
JF - Gastro Hep Advances
IS - 6
ER -