Gastrointestinal symptoms in Parkinson's disease

L. L. Edwards, R. F. Pfeiffer, E. M.M. Quigley, Ruth Hofman, Mary Balluff

Research output: Contribution to journalArticlepeer-review

334 Scopus citations


We have investigated the prevalence of gastrointestinal (GI) symptoms in 98 individuals with Parkinson's disease (PD) and in a control group of 50. Seventy‐nine of those with PD were being treated with dopaminergic medications and 19 were untreated. Those symptoms occurring more frequently in PD patients than in controls included abnormal salivation, dysphagia, nausea, constipation, and defecatory dysfunction. Except for defecatory dysfunction, symptoms did not correlate with treatment but instead correlated with disease severity. This suggests that the GI symptoms of PD reflect direct involvement in the GI tract by the primary disease process.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalMovement Disorders
Issue number2
StatePublished - 1991
Externally publishedYes


  • Gastrointestinal dysfunction
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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