TY - JOUR
T1 - Genetic correlational analyses of ethanol reward and aversion phenotypes in short-term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion
AU - Phillips, Tamara J.
AU - Broadbent, Julie
AU - Burkhart-Kasch, Sue
AU - Henderson, Carly
AU - Wenger, Charlotte D.
AU - McMullin, Carrie
AU - McKinnon, Carrie S.
AU - Cunningham, Christopher L.
PY - 2005/8
Y1 - 2005/8
N2 - Short-term selective breeding created mouse lines divergent for ethanol drinking (high drinking short-term selected line [STDRHI], low drinking [STDRLO]) or ethanol-induced conditioned taste aversion (CTA; high [HTA], low [LTA]). Compared with STDRLO, STDRHI mice consumed more saccharin and less quinine, exhibited greater ethanol-induced conditioned place preference (CPP), and showed reduced ethanol stimulation and sensitization under some conditions; a line difference in ethanol-induced CTA was not consistently found. Compared with LTA, HTA mice consumed less ethanol but were similar in saccharin consumption, sensitivity to ethanol-induced CPP, and ethanol-induced locomotor stimulation and sensitization. These data suggest that ethanol drinking is genetically associated with several reward- and aversion-related traits. The interpretation of ethanol-induced CTA as more genetically distinct must be tempered by the inability to test the CTA lines beyond Selection Generation 2.
AB - Short-term selective breeding created mouse lines divergent for ethanol drinking (high drinking short-term selected line [STDRHI], low drinking [STDRLO]) or ethanol-induced conditioned taste aversion (CTA; high [HTA], low [LTA]). Compared with STDRLO, STDRHI mice consumed more saccharin and less quinine, exhibited greater ethanol-induced conditioned place preference (CPP), and showed reduced ethanol stimulation and sensitization under some conditions; a line difference in ethanol-induced CTA was not consistently found. Compared with LTA, HTA mice consumed less ethanol but were similar in saccharin consumption, sensitivity to ethanol-induced CPP, and ethanol-induced locomotor stimulation and sensitization. These data suggest that ethanol drinking is genetically associated with several reward- and aversion-related traits. The interpretation of ethanol-induced CTA as more genetically distinct must be tempered by the inability to test the CTA lines beyond Selection Generation 2.
KW - Alcohol
KW - Conditioned place preference
KW - Locomotor stimulation
KW - Saccharin preference
KW - Sensitization
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UR - http://www.scopus.com/inward/citedby.url?scp=18844379461&partnerID=8YFLogxK
U2 - 10.1037/0735-7044.119.4.892
DO - 10.1037/0735-7044.119.4.892
M3 - Article
C2 - 16187818
AN - SCOPUS:18844379461
SN - 0735-7044
VL - 119
SP - 892
EP - 910
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
IS - 4
ER -