TY - JOUR
T1 - Genetic polymorphisms associated with the risk of concussion in 1056 college athletes
T2 - A multicentre prospective cohort study
AU - Terrell, Thomas Roland
AU - Abramson, Ruth
AU - Barth, Jeffery T.
AU - Bennett, Ellen
AU - Cantu, Robert C.
AU - Sloane, Richard
AU - Laskowitz, Daniel T.
AU - Erlanger, David M.
AU - McKeag, Douglas
AU - Nichols, Gregory
AU - Valentine, Verle
AU - Galloway, Leslie
N1 - Publisher Copyright:
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
PY - 2018/2
Y1 - 2018/2
N2 - Background/aim To evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser 53 Pro, MAPT/tau Hist 47 Tyr, IL-6572 G/C and IL-6R Asp 358 Ala with the risk of concussion in college athletes. Methods A 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion. Results The study cohort consisted of 1056 athletes of mean±SD age 19.7±1.5 years, 89.3% male, 59.4% Caucasian, 35.0% African-American, 5.6% other race. The athletes participated in American football, soccer, basketball, softball, men's wrestling and club rugby. A total of 133 (12.1% prevalence) concussions occurred during an average surveillance of 3 years per athlete. We observed a significant positive association between IL-6R CC (p=0.001) and a negative association between APOE4 (p=0.03) and the risk of concussion. Unadjusted and adjusted logistic regression analysis showed a significant association between IL-6R CC and concussion (OR 3.48; 95% CI 1.58 to 7.65; p=0.002) and between the APOE4 allele and concussion (OR 0.61; 95% CI 0.38 to 0.96; p=0.04), which persisted after adjustment for confounders. Conclusions IL-6R CC was associated with a three times greater concussion risk and APOE4 with a 40% lower risk.
AB - Background/aim To evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser 53 Pro, MAPT/tau Hist 47 Tyr, IL-6572 G/C and IL-6R Asp 358 Ala with the risk of concussion in college athletes. Methods A 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion. Results The study cohort consisted of 1056 athletes of mean±SD age 19.7±1.5 years, 89.3% male, 59.4% Caucasian, 35.0% African-American, 5.6% other race. The athletes participated in American football, soccer, basketball, softball, men's wrestling and club rugby. A total of 133 (12.1% prevalence) concussions occurred during an average surveillance of 3 years per athlete. We observed a significant positive association between IL-6R CC (p=0.001) and a negative association between APOE4 (p=0.03) and the risk of concussion. Unadjusted and adjusted logistic regression analysis showed a significant association between IL-6R CC and concussion (OR 3.48; 95% CI 1.58 to 7.65; p=0.002) and between the APOE4 allele and concussion (OR 0.61; 95% CI 0.38 to 0.96; p=0.04), which persisted after adjustment for confounders. Conclusions IL-6R CC was associated with a three times greater concussion risk and APOE4 with a 40% lower risk.
KW - APOE4
KW - IL-6 gene
KW - genotype
KW - sport
KW - traumatic brain injury
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U2 - 10.1136/bjsports-2016-097419
DO - 10.1136/bjsports-2016-097419
M3 - Article
C2 - 28918391
AN - SCOPUS:85041842124
SN - 0306-3674
VL - 52
SP - 192
EP - 198
JO - British journal of sports medicine
JF - British journal of sports medicine
IS - 3
ER -