Abstract
Cardiac development is the result of genetic programs modulated by in utero environmental factors. As such, cardiac malformations leading to congenital heart disease (CHD) can result from either genetic anomalies or abnormal in utero conditions. Environmental factors that can lead to CHD include abnormal blood flow conditions in the heart, maternal diabetes, and teratogens, among others. The placenta is the organ of pregnancy that regulates the exchange of substances between mother and embryo, and it also influences cardiovascular circulation in the baby. Thus, development of the cardiovascular system and the placenta are crucially interlinked. In vivo and postmortem imaging techniques can be used to determine how placenta formation affects cardiovascular development and cardiovascular function in mouse models.
| Original language | English (US) |
|---|---|
| Title of host publication | The Guide to Investigation of Mouse Pregnancy |
| Publisher | Elsevier |
| Pages | 431-442 |
| Number of pages | 12 |
| ISBN (Electronic) | 9780123944450 |
| ISBN (Print) | 9780123947949 |
| DOIs | |
| State | Published - Jan 1 2014 |
Keywords
- 3D cardiac imaging
- Blood velocity
- Cardiac function
- Cardiac reconstruction
- Cardiac segmentation
- Computed tomography
- Confocal
- Doppler velocity
- Echocardiography
ASJC Scopus subject areas
- General Medicine