TY - JOUR
T1 - GET FIT
T2 - A Randomized Clinical Trial of Tai Ji Quan Versus Strength Training for Fall Prevention After Chemotherapy in Older, Postmenopausal Women Cancer Survivors
AU - Winters-Stone, Kerri M.
AU - Horak, Fay
AU - Dieckmann, Nathan F.
AU - Luoh, Shiuh Wen
AU - Eckstrom, Elizabeth
AU - Stoyles, Sydnee A.
AU - Roeland, Eric J.
AU - Li, Fuzhong
N1 - Publisher Copyright:
© American Society of Clinical Oncology.
PY - 2023/6/20
Y1 - 2023/6/20
N2 - PURPOSETo compare the efficacy of tai ji quan versus strength training to prevent falls after chemotherapy in older, postmenopaual women.METHODSWe conducted a three-arm, single-blind, randomized controlled trial where older (50+ years), postmenopausal women cancer survivors participated in one of three supervised group exercise programs (tai ji quan, strength training, or stretching control) twice weekly for 6 months and were followed up 6 months after training stopped. The primary outcome was the incidence of falls. Secondary outcomes included fall-related injuries, leg strength (1 repetition maximum; kg), and balance (sensory organization [equilibrium score] and limits of stability [LOS; %] tests).RESULTSFour hundred sixty-two women were enrolled (mean age, 62 ± 6.3 years). Retention was 93%, and adherence averaged 72.9%. In primary analysis, there was no difference in the incidence of falls between groups after 6 months of training, nor during 6-month follow-up. A post hoc analysis detected a significantly reduced incidence of fall-related injuries within the tai ji quan group over the first 6 months, dropping from 4.3 falls per 100 person-months (95% CI, 2.9 to 5.6) at baseline to 2.4 falls per person-months (95% CI, 1.2 to 3.5). No significant changes occurred during 6-month follow-up. Over the intervention period, leg strength significantly improved in the strength group and balance (LOS) improved in the tai ji quan group, compared with controls (P <.05).CONCLUSIONWe found no significant reduction in falls for tai ji quan or strength training relative to stretching control in postmenopausal women treated with chemotherapy.
AB - PURPOSETo compare the efficacy of tai ji quan versus strength training to prevent falls after chemotherapy in older, postmenopaual women.METHODSWe conducted a three-arm, single-blind, randomized controlled trial where older (50+ years), postmenopausal women cancer survivors participated in one of three supervised group exercise programs (tai ji quan, strength training, or stretching control) twice weekly for 6 months and were followed up 6 months after training stopped. The primary outcome was the incidence of falls. Secondary outcomes included fall-related injuries, leg strength (1 repetition maximum; kg), and balance (sensory organization [equilibrium score] and limits of stability [LOS; %] tests).RESULTSFour hundred sixty-two women were enrolled (mean age, 62 ± 6.3 years). Retention was 93%, and adherence averaged 72.9%. In primary analysis, there was no difference in the incidence of falls between groups after 6 months of training, nor during 6-month follow-up. A post hoc analysis detected a significantly reduced incidence of fall-related injuries within the tai ji quan group over the first 6 months, dropping from 4.3 falls per 100 person-months (95% CI, 2.9 to 5.6) at baseline to 2.4 falls per person-months (95% CI, 1.2 to 3.5). No significant changes occurred during 6-month follow-up. Over the intervention period, leg strength significantly improved in the strength group and balance (LOS) improved in the tai ji quan group, compared with controls (P <.05).CONCLUSIONWe found no significant reduction in falls for tai ji quan or strength training relative to stretching control in postmenopausal women treated with chemotherapy.
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U2 - 10.1200/JCO.22.01519
DO - 10.1200/JCO.22.01519
M3 - Article
C2 - 36888933
AN - SCOPUS:85163616450
SN - 0732-183X
VL - 41
SP - 3384
EP - 3396
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 18
ER -