Glial cell component in retinoblastoma

Joseph L. Craft, Delia N. Sang, Thaddeus P. Dryja, Robert J. Brockhurst, Nancy L. Robinson, Daniel M. Albert

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The right eye of a 4-month-old girl with a large, unilateral, sporadic retinoblastoma was enucleated. The tumor was unusual because it contained Flexner-Wintersteiner rosettes with extremely large lumina. Smaller rosettes and undifferentiated tumor cells were observed within the lumina. Also of importance were cells resembling glial cells which were intermixed with more typical cuboidal retinoblastoma cells. These cells had electron microscopic features typical of glial cells and stained positively for glial fibrillary acidic protein in immunohistochemical studies. Rosettes and glial cells continued to be observed in the tumor carried in tissue culture through two passages over a 7-month period. This tumor is presented because of its unusual rosette structures and because it confirms recent reports describing a glial cell component in retinoblastoma.

Original languageEnglish (US)
Pages (from-to)647-656,IN1-IN2,657-659
JournalExperimental Eye Research
Issue number5
StatePublished - May 1985
Externally publishedYes


  • glial cells
  • retinoblastoma

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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