Global rural health disparities in Alzheimer's disease and related dementias: State of the science

Lisa Ann Kirk Wiese; Allison Gibson; Marc Aaron Guest; Amy R. Nelson; Raven Weaver; Aditi Gupta; Owen Carmichael; Jordan P. Lewis; Allison Lindauer; Samantha Loi; Rachel Peterson; Kylie Radford; Elizabeth K. Rhodus; Christina G. Wong; Megan Zuelsdorff; Ladan Ghazi Saidi; Esmeralda Valdivieso-Mora; Sanne Franzen; Caitlin N. Pope; Timothy S. Killian; Hom L. Shrestha; Patricia C. Heyn; Ted Kheng Siang Ng; Beth Prusaczyk; Samantha John; Ambar Kulshreshtha; Julia L. Sheffler; Lilah Besser; Valerie Daniel; Magdalena I. Tolea; Justin Miller; Christine Musyimi; Jon Corkey; Veronica Yank; Christine L. Williams; Zahra Rahemi; Ju Young Park; Sheryl Magzamen; Robert L. Newton; Candace Harrington; Jason D. Flatt; Sonakshi Arora; Sarah Walter; Percy Griffin; Ganesh M. Babulal

doi:10.1002/alz.13104

Global rural health disparities in Alzheimer's disease and related dementias: State of the science

Lisa Ann Kirk Wiese, Allison Gibson, Marc Aaron Guest, Amy R. Nelson, Raven Weaver, Aditi Gupta, Owen Carmichael, Jordan P. Lewis, Allison Lindauer, Samantha Loi, Rachel Peterson, Kylie Radford, Elizabeth K. Rhodus, Christina G. Wong, Megan Zuelsdorff, Ladan Ghazi Saidi, Esmeralda Valdivieso-Mora, Sanne Franzen, Caitlin N. Pope, Timothy S. KillianHom L. Shrestha, Patricia C. Heyn, Ted Kheng Siang Ng, Beth Prusaczyk, Samantha John, Ambar Kulshreshtha, Julia L. Sheffler, Lilah Besser, Valerie Daniel, Magdalena I. Tolea, Justin Miller, Christine Musyimi, Jon Corkey, Veronica Yank, Christine L. Williams, Zahra Rahemi, Ju Young Park, Sheryl Magzamen, Robert L. Newton, Candace Harrington, Jason D. Flatt, Sonakshi Arora, Sarah Walter, Percy Griffin, Ganesh M. Babulal

Neurology

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

INTRODUCTION: Individuals living in rural communities are at heightened risk for Alzheimer's disease and related dementias (ADRD), which parallels other persistent place-based health disparities. Identifying multiple potentially modifiable risk factors specific to rural areas that contribute to ADRD is an essential first step in understanding the complex interplay between various barriers and facilitators. METHODS: An interdisciplinary, international group of ADRD researchers convened to address the overarching question of: “What can be done to begin minimizing the rural health disparities that contribute uniquely to ADRD?” In this state of the science appraisal, we explore what is known about the biological, behavioral, sociocultural, and environmental influences on ADRD disparities in rural settings. RESULTS: A range of individual, interpersonal, and community factors were identified, including strengths of rural residents in facilitating healthy aging lifestyle interventions. DISCUSSION: A location dynamics model and ADRD-focused future directions are offered for guiding rural practitioners, researchers, and policymakers in mitigating rural disparities. HIGHLIGHTS: Rural residents face heightened Alzheimer's disease and related dementia (ADRD) risks and burdens due to health disparities. Defining the unique rural barriers and facilitators to cognitive health yields insight. The strengths and resilience of rural residents can mitigate ADRD-related challenges. A novel “location dynamics” model guides assessment of rural-specific ADRD issues.

Original language	English (US)
Pages (from-to)	4204-4225
Number of pages	22
Journal	Alzheimer's and Dementia
Volume	19
Issue number	9
DOIs	https://doi.org/10.1002/alz.13104
State	Published - Sep 2023

Keywords

community engagement
community-based action
facilitators and barriers to ADRD diagnosis and treatment
global disparities
health disparities
location dynamics
modifiable ADRD risk factors
rural
rural culture
under-represented
underserved

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1002/alz.13104

Cite this

Wiese, L. A. K., Gibson, A., Guest, M. A., Nelson, A. R., Weaver, R., Gupta, A., Carmichael, O., Lewis, J. P., Lindauer, A., Loi, S., Peterson, R., Radford, K., Rhodus, E. K., Wong, C. G., Zuelsdorff, M., Saidi, L. G., Valdivieso-Mora, E., Franzen, S., Pope, C. N., ... Babulal, G. M. (2023). Global rural health disparities in Alzheimer's disease and related dementias: State of the science. Alzheimer's and Dementia, 19(9), 4204-4225. https://doi.org/10.1002/alz.13104

Wiese, LAK, Gibson, A, Guest, MA, Nelson, AR, Weaver, R, Gupta, A, Carmichael, O, Lewis, JP, Lindauer, A, Loi, S, Peterson, R, Radford, K, Rhodus, EK, Wong, CG, Zuelsdorff, M, Saidi, LG, Valdivieso-Mora, E, Franzen, S, Pope, CN, Killian, TS, Shrestha, HL, Heyn, PC, Ng, TKS, Prusaczyk, B, John, S, Kulshreshtha, A, Sheffler, JL, Besser, L, Daniel, V, Tolea, MI, Miller, J, Musyimi, C, Corkey, J, Yank, V, Williams, CL, Rahemi, Z, Park, JY, Magzamen, S, Newton, RL, Harrington, C, Flatt, JD, Arora, S, Walter, S, Griffin, P & Babulal, GM 2023, 'Global rural health disparities in Alzheimer's disease and related dementias: State of the science', Alzheimer's and Dementia, vol. 19, no. 9, pp. 4204-4225. https://doi.org/10.1002/alz.13104

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title = "Global rural health disparities in Alzheimer's disease and related dementias: State of the science",

abstract = "INTRODUCTION: Individuals living in rural communities are at heightened risk for Alzheimer's disease and related dementias (ADRD), which parallels other persistent place-based health disparities. Identifying multiple potentially modifiable risk factors specific to rural areas that contribute to ADRD is an essential first step in understanding the complex interplay between various barriers and facilitators. METHODS: An interdisciplinary, international group of ADRD researchers convened to address the overarching question of: “What can be done to begin minimizing the rural health disparities that contribute uniquely to ADRD?” In this state of the science appraisal, we explore what is known about the biological, behavioral, sociocultural, and environmental influences on ADRD disparities in rural settings. RESULTS: A range of individual, interpersonal, and community factors were identified, including strengths of rural residents in facilitating healthy aging lifestyle interventions. DISCUSSION: A location dynamics model and ADRD-focused future directions are offered for guiding rural practitioners, researchers, and policymakers in mitigating rural disparities. HIGHLIGHTS: Rural residents face heightened Alzheimer's disease and related dementia (ADRD) risks and burdens due to health disparities. Defining the unique rural barriers and facilitators to cognitive health yields insight. The strengths and resilience of rural residents can mitigate ADRD-related challenges. A novel “location dynamics” model guides assessment of rural-specific ADRD issues.",

keywords = "community engagement, community-based action, facilitators and barriers to ADRD diagnosis and treatment, global disparities, health disparities, location dynamics, modifiable ADRD risk factors, rural, rural culture, under-represented, underserved",

author = "Wiese, {Lisa Ann Kirk} and Allison Gibson and Guest, {Marc Aaron} and Nelson, {Amy R.} and Raven Weaver and Aditi Gupta and Owen Carmichael and Lewis, {Jordan P.} and Allison Lindauer and Samantha Loi and Rachel Peterson and Kylie Radford and Rhodus, {Elizabeth K.} and Wong, {Christina G.} and Megan Zuelsdorff and Saidi, {Ladan Ghazi} and Esmeralda Valdivieso-Mora and Sanne Franzen and Pope, {Caitlin N.} and Killian, {Timothy S.} and Shrestha, {Hom L.} and Heyn, {Patricia C.} and Ng, {Ted Kheng Siang} and Beth Prusaczyk and Samantha John and Ambar Kulshreshtha and Sheffler, {Julia L.} and Lilah Besser and Valerie Daniel and Tolea, {Magdalena I.} and Justin Miller and Christine Musyimi and Jon Corkey and Veronica Yank and Williams, {Christine L.} and Zahra Rahemi and Park, {Ju Young} and Sheryl Magzamen and Newton, {Robert L.} and Candace Harrington and Flatt, {Jason D.} and Sonakshi Arora and Sarah Walter and Percy Griffin and Babulal, {Ganesh M.}",

note = "Publisher Copyright: {\textcopyright} 2023 the Alzheimer's Association.",

year = "2023",

month = sep,

doi = "10.1002/alz.13104",

language = "English (US)",

volume = "19",

pages = "4204--4225",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "Elsevier Inc.",

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T1 - Global rural health disparities in Alzheimer's disease and related dementias

T2 - State of the science

AU - Wiese, Lisa Ann Kirk

AU - Gibson, Allison

AU - Guest, Marc Aaron

AU - Nelson, Amy R.

AU - Weaver, Raven

AU - Gupta, Aditi

AU - Carmichael, Owen

AU - Lewis, Jordan P.

AU - Lindauer, Allison

AU - Loi, Samantha

AU - Peterson, Rachel

AU - Radford, Kylie

AU - Rhodus, Elizabeth K.

AU - Wong, Christina G.

AU - Zuelsdorff, Megan

AU - Saidi, Ladan Ghazi

AU - Valdivieso-Mora, Esmeralda

AU - Franzen, Sanne

AU - Pope, Caitlin N.

AU - Killian, Timothy S.

AU - Shrestha, Hom L.

AU - Heyn, Patricia C.

AU - Ng, Ted Kheng Siang

AU - Prusaczyk, Beth

AU - John, Samantha

AU - Kulshreshtha, Ambar

AU - Sheffler, Julia L.

AU - Besser, Lilah

AU - Daniel, Valerie

AU - Tolea, Magdalena I.

AU - Miller, Justin

AU - Musyimi, Christine

AU - Corkey, Jon

AU - Yank, Veronica

AU - Williams, Christine L.

AU - Rahemi, Zahra

AU - Park, Ju Young

AU - Magzamen, Sheryl

AU - Newton, Robert L.

AU - Harrington, Candace

AU - Flatt, Jason D.

AU - Arora, Sonakshi

AU - Walter, Sarah

AU - Griffin, Percy

AU - Babulal, Ganesh M.

PY - 2023/9

Y1 - 2023/9

N2 - INTRODUCTION: Individuals living in rural communities are at heightened risk for Alzheimer's disease and related dementias (ADRD), which parallels other persistent place-based health disparities. Identifying multiple potentially modifiable risk factors specific to rural areas that contribute to ADRD is an essential first step in understanding the complex interplay between various barriers and facilitators. METHODS: An interdisciplinary, international group of ADRD researchers convened to address the overarching question of: “What can be done to begin minimizing the rural health disparities that contribute uniquely to ADRD?” In this state of the science appraisal, we explore what is known about the biological, behavioral, sociocultural, and environmental influences on ADRD disparities in rural settings. RESULTS: A range of individual, interpersonal, and community factors were identified, including strengths of rural residents in facilitating healthy aging lifestyle interventions. DISCUSSION: A location dynamics model and ADRD-focused future directions are offered for guiding rural practitioners, researchers, and policymakers in mitigating rural disparities. HIGHLIGHTS: Rural residents face heightened Alzheimer's disease and related dementia (ADRD) risks and burdens due to health disparities. Defining the unique rural barriers and facilitators to cognitive health yields insight. The strengths and resilience of rural residents can mitigate ADRD-related challenges. A novel “location dynamics” model guides assessment of rural-specific ADRD issues.

AB - INTRODUCTION: Individuals living in rural communities are at heightened risk for Alzheimer's disease and related dementias (ADRD), which parallels other persistent place-based health disparities. Identifying multiple potentially modifiable risk factors specific to rural areas that contribute to ADRD is an essential first step in understanding the complex interplay between various barriers and facilitators. METHODS: An interdisciplinary, international group of ADRD researchers convened to address the overarching question of: “What can be done to begin minimizing the rural health disparities that contribute uniquely to ADRD?” In this state of the science appraisal, we explore what is known about the biological, behavioral, sociocultural, and environmental influences on ADRD disparities in rural settings. RESULTS: A range of individual, interpersonal, and community factors were identified, including strengths of rural residents in facilitating healthy aging lifestyle interventions. DISCUSSION: A location dynamics model and ADRD-focused future directions are offered for guiding rural practitioners, researchers, and policymakers in mitigating rural disparities. HIGHLIGHTS: Rural residents face heightened Alzheimer's disease and related dementia (ADRD) risks and burdens due to health disparities. Defining the unique rural barriers and facilitators to cognitive health yields insight. The strengths and resilience of rural residents can mitigate ADRD-related challenges. A novel “location dynamics” model guides assessment of rural-specific ADRD issues.

KW - community engagement

KW - community-based action

KW - facilitators and barriers to ADRD diagnosis and treatment

KW - global disparities

KW - health disparities

KW - location dynamics

KW - modifiable ADRD risk factors

KW - rural

KW - rural culture

KW - under-represented

KW - underserved

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U2 - 10.1002/alz.13104

DO - 10.1002/alz.13104

M3 - Review article

C2 - 37218539

AN - SCOPUS:85159864456

SN - 1552-5260

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JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

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ER -

Global rural health disparities in Alzheimer's disease and related dementias: State of the science

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Keywords

ASJC Scopus subject areas

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