Glutamate receptors regulate actin-based plasticity in dendritic spines

Maria Fischer, Stefanie Kaech, Uta Wagner, Heike Brinkhaus, Andrew Matus

Research output: Contribution to journalArticlepeer-review

224 Scopus citations


Dendritic spines at excitatory synapses undergo rapid, actin-dependent shape changes which may contribute to plasticity in brain circuits. Here we show that actin dynamics in spines are potently inhibited by activation of either AMPA or NMDA subtype glutamate receptors. Activation of either receptor type inhibited actin-based protrusive activity from the spine head. This blockade of motility caused spines to round up so that spine morphology became both more stable and more regular. Inhibition of spine motility by AMPA receptors was dependent on postsynaptic membrane depolarization and influx of Ca2+ through voltage-activated channels. In combination with previous studies, our results suggest a two-step process in which spines initially formed in response to NMDA receptor activation are subsequently stabilized by AMPA receptors.

Original languageEnglish (US)
Pages (from-to)887-894
Number of pages8
JournalNature Neuroscience
Issue number9
StatePublished - Sep 2000
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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