Abstract
We developed a handheld optical coherence tomography angiography (OCTA) system using a 100-kHz swept-source laser. The handheld probe weighs 0.4 kg and measures 20.6 × 12.8 × 4.6 cm3. The system has dedicated features for handheld operation. The probe is equipped with a mini iris camera for easy alignment. Real-time display of the en face OCT and cross-sectional OCT images in the system allows accurately locating the imaging target. Fast automatic focusing was achieved by an electrically tunable lens controlled by a golden-section search algorithm. An extended axial imaging range of 6 mm allows easy alignment. A registration algorithm using cross-correlation to register adjacent OCT B-frames with propagation from the central frame was used to effectively minimize motion artifacts in volumetric OCTA images captured in relatively short durations of 1 and 2.1 seconds. 2.5 × 2.5 mm (200 × 200 pixels) and 3.5 × 3.5 mm (300 × 300 pixels) retinal angiograms were demonstrated on two awake adult human subjects without the use of any mydriatic eye drops.
Original language | English (US) |
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Article number | #282470 |
Pages (from-to) | 2287-2300 |
Number of pages | 14 |
Journal | Biomedical Optics Express |
Volume | 8 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2017 |
Keywords
- Medical and biological imaging
- Ophthalmic optics and devices
- Optical coherence tomography
ASJC Scopus subject areas
- Biotechnology
- Atomic and Molecular Physics, and Optics