Head and neck hemangiomas of infancy

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


PURPOSE OF REVIEW: Hemangiomas are the most common benign tumor in infancy, affecting approximately 10% of infants. More than half of hemangiomas involve the head and neck. Increased understanding of hemangiomas has come about from identification of immunohistochemical markers, developmental defects associated with certain hemangiomas, and morphologic and classification schemes (focal versus segmental). RECENT FINDINGS: Immunohistochemical markers have been identified which are specific to hemangiomas in all phases of development and involution. Morphologic subtypes and anatomic locations have been identified that place an infant at higher risk for complications from the hemangioma. Hemangiomas associated with other developmental anomalies have been identified, which help guide the treating physician to tease out which infants will need more complete systemic investigations or imaging. Importantly for surgeons, studies have continued to identify which lesions may benefit from early intervention, either surgical or medical. SUMMARY: While full understanding of the mechanisms that turn on and turn off hemangiomas of infancy is not complete, progress has been made in identification of markers, subtypes at increased risk for complications, and in treatment. With continued work in these areas, we have increased knowledge of treatment options, optimal timing of surgical intervention, and ultimately, preventive options.

Original languageEnglish (US)
Pages (from-to)397-405
Number of pages9
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Issue number6
StatePublished - Dec 2006


  • Glut-1
  • Hemangiomas of infancy
  • PHACE(S) association
  • Segmental hemangioma

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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