Hematocrit dependence of flow signal in optical coherence tomography angiography

Jianlong Yang, Johnny Su, Jie Wang, Silu Men, Yali Jia, David Huang, Gangjun Liu

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The hematocrit dependence of flow signal (split-spectrum amplitude decorrelation angiography-SSADA decorrelation value) was investigated in this paper. Based on the normalized field temporal correlation function and concentration dependent particle scattering properties, the relationship between hematocrit and flow signal was analytically derived. Experimental verification of the relationship was performed with custom-designed microfluidic chips and human blood with 45%, 40% and 32% hematocrit. It was found that, in large flow channels and blood vessels, the normal hematocrit is near the decorrelation saturation point and therefore a change in hematocrit has little effect on the SSADA decorrelation value (flow signal). However, in narrow channels in the capillary size range, the effective hematocrit (adjusted for the overlap between OCT beam and channel) is in the range of 6.7-9.5% and therefore variation in hematocrit does significantly affect the flow signal.

Original languageEnglish (US)
Article number#276240
Pages (from-to)776-789
Number of pages14
JournalBiomedical Optics Express
Issue number2
StatePublished - Feb 1 2017


  • Medical and biological imaging
  • Ophthalmic optics and devices
  • Optical coherence tomography

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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