Hemostatic complications associated with ventricular assist devices

Talal Hilal, James Mudd, Thomas G. DeLoughery

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Hemostatic complications are common in patients with ventricular assist devices. The pathophysiologic mechanisms that lead to dysregulated hemostasis involve complex interactions between device surface, sheer stress, and blood flow. These factors lead to various manifestations that require a thorough understanding of the interplay among platelets, coagulation factors, and red cells. In this article, we review the pathophysiology of hematologic complications (bleeding, acquired von Willebrand disease, heparin-induced thrombocytopenia, hemolysis, stroke and pump thrombosis), the clinical manifestations, and the management of each. We summarize the evidence available for management of these entities and provide a pragmatic clinical review.

Original languageEnglish (US)
Pages (from-to)589-598
Number of pages10
JournalResearch and Practice in Thrombosis and Haemostasis
Issue number4
StatePublished - Oct 1 2019


  • heart-assist devices
  • hemostasis
  • heparin-induced thrombocytopenia
  • thrombosis
  • ventricular assist devices
  • von Willebrand diseases

ASJC Scopus subject areas

  • Hematology


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