TY - JOUR
T1 - Hereditary considerations in common disorders.
AU - Anderson, C. E.
AU - Rotter, J. I.
AU - Zonana, J.
N1 - Funding Information:
Supported in part by U. S. Public Health Service Grant AM 17328. Dr. Rotter is the recipient of NIAMDD Postdoctoral Research Fellowship Award AM 050602.
PY - 1978/8
Y1 - 1978/8
N2 - We have reviewed the approach of the modern clinical geneticist to the genetics of common diseases. The importance of considering genetic heterogeneity within these groups of disorders has been emphasized. The physician should recognize our present inability to deliver exact recurrence risks for most families with these common disorders. As our knowledge improves, we must constantly update our counseling. Until then, in most cases, we can only utilize the empirical risk data presently available and provide an idea of the magnitude of risk, which in many of these disorders appears low. However, continued utilization of imprecise risk data must not impede recognition of potential and demonstrated heterogeneity within these disorders, or retard the development of new and improved risk data based on knowledge of the heterogeneity within common diseases.
AB - We have reviewed the approach of the modern clinical geneticist to the genetics of common diseases. The importance of considering genetic heterogeneity within these groups of disorders has been emphasized. The physician should recognize our present inability to deliver exact recurrence risks for most families with these common disorders. As our knowledge improves, we must constantly update our counseling. Until then, in most cases, we can only utilize the empirical risk data presently available and provide an idea of the magnitude of risk, which in many of these disorders appears low. However, continued utilization of imprecise risk data must not impede recognition of potential and demonstrated heterogeneity within these disorders, or retard the development of new and improved risk data based on knowledge of the heterogeneity within common diseases.
UR - http://www.scopus.com/inward/record.url?scp=0018000270&partnerID=8YFLogxK
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U2 - 10.1016/S0031-3955(16)33603-3
DO - 10.1016/S0031-3955(16)33603-3
M3 - Article
C2 - 358108
AN - SCOPUS:0018000270
SN - 0031-3955
VL - 25
SP - 539
EP - 556
JO - Pediatric clinics of North America
JF - Pediatric clinics of North America
IS - 3
ER -