TY - JOUR
T1 - High-dose growth hormone treatment of short children born small for gestational age
AU - De Zegher, Francis
AU - Maes, Marc
AU - Gargosky, Sharron E.
AU - Heinrichs, Claudine
AU - Du Caju, Marc V.L.
AU - Thiry, Geneviève
AU - De Schepper, Jean
AU - Craen, Margareta
AU - Breysem, Luc
AU - Löfström, Annika
AU - Jönsson, Peter
AU - Bourguignon, Jean Pierre
AU - Malvaux, Paul
AU - Rosenfeld, Ron G.
PY - 1996
Y1 - 1996
N2 - The effect of GH administration was evaluated over 2 yr in 50 short, prepubertal, non-GH deficient children born small for gestational age, who had been randomly allocated to a group receiving no treatment or daily sc GH treatment at a dose of 0.2 or 0.3 IU/kg. At the start of the study, mean age was 5.2 yr, bone age was 4.0 yr, height SDS was -3.5, height velocity SDS was -0.8, weight SDS was -2.7, and body mass index SDS was -1.9. Catch-up growth was observed in none of the untreated and all of the treated children. The response to GH treatment included a near doubling of growth velocity and of weight gain and a mean height increment of more than 2 SDS. GH treatment was associated with a distinct acceleration of bone maturation. The differences between the growth responses evoked by the two GH doses were minor. The prepubertal GH-induced catch-up growth was associated with elevated serum concentrations of insulin, insulin-like growth factor-I, insulin-like growth factor binding protein-3, and osteocalcin, whereas insulin-like growth factor-II levels remained unaltered. GH treatment was well tolerated. In conclusion, high-dose GH administration over 2 yr is emerging as a potential therapy to increase the short stature that results from insufficient catch- up growth in young children born small for gestational age. The long-term impact of this approach remains to be delineated.
AB - The effect of GH administration was evaluated over 2 yr in 50 short, prepubertal, non-GH deficient children born small for gestational age, who had been randomly allocated to a group receiving no treatment or daily sc GH treatment at a dose of 0.2 or 0.3 IU/kg. At the start of the study, mean age was 5.2 yr, bone age was 4.0 yr, height SDS was -3.5, height velocity SDS was -0.8, weight SDS was -2.7, and body mass index SDS was -1.9. Catch-up growth was observed in none of the untreated and all of the treated children. The response to GH treatment included a near doubling of growth velocity and of weight gain and a mean height increment of more than 2 SDS. GH treatment was associated with a distinct acceleration of bone maturation. The differences between the growth responses evoked by the two GH doses were minor. The prepubertal GH-induced catch-up growth was associated with elevated serum concentrations of insulin, insulin-like growth factor-I, insulin-like growth factor binding protein-3, and osteocalcin, whereas insulin-like growth factor-II levels remained unaltered. GH treatment was well tolerated. In conclusion, high-dose GH administration over 2 yr is emerging as a potential therapy to increase the short stature that results from insufficient catch- up growth in young children born small for gestational age. The long-term impact of this approach remains to be delineated.
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U2 - 10.1210/jc.81.5.1887
DO - 10.1210/jc.81.5.1887
M3 - Article
C2 - 8626853
AN - SCOPUS:9344229218
SN - 0021-972X
VL - 81
SP - 1887
EP - 1892
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 5
ER -