TY - JOUR
T1 - High-speed Optical Coherence Tomography of Corneal Opacities
AU - Khurana, Rahul N.
AU - Li, Yan
AU - Tang, Maolong
AU - Lai, Michael M.
AU - Huang, David
N1 - Funding Information:
Supported by the National Institutes of Health, Bethesda, Maryland (grant no. P30 EY03040), and Carl Zeiss Meditec, Inc., Dublin, California.
PY - 2007/7
Y1 - 2007/7
N2 - Purpose: To evaluate corneal opacities with optical coherence tomography (OCT). Design: Prospective observational case series. Participants: Twenty-three eyes of 19 patients with corneal opacities referred to a tertiary medical center. Methods: Twenty-three consecutive eyes with corneal opacities were imaged with a high-speed corneal OCT prototype (Carl Zeiss Meditec, Inc., Dublin, CA). The OCT system operates at a speed of 2000 axial scans per second and a wavelength of 1.3 μm. Slit-scanning tomography (Orbscan II, software version 3.12; Bausch & Lomb, Inc., Rochester, NY) and ultrasound pachymetry (Corneo-Gage Plus; Sonogage, Cleveland, OH) also were performed. Main Outcome Measures: Central cornea thickness was measured by the 3 instruments. Results: In eyes with central opacities (n = 17), OCT central cornea thickness measurements were statistically equivalent to ultrasound pachymetry, whereas Orbscan II measurements were significantly less than ultrasound pachymetry (difference, -132.7±143 μm; P = 0.006). The OCT and ultrasound pachymetry results were obtained for all eyes, whereas Orbscan was unable to provide readings in 4 eyes. In eyes with off-center opacities (n = 6), OCT and Orbscan II central cornea thickness measurements were statistically equivalent to ultrasound pachymetry. The OCT measurements of epithelial thickness and scar depth also were demonstrated. Conclusions: Optical coherence tomography provides consistent pachymetry mapping, whereas Orbscan II significantly underestimates corneal thickness in the presence of central corneal scars. Optical coherence tomography could be valuable in the planning of surgical treatment of corneal scars.
AB - Purpose: To evaluate corneal opacities with optical coherence tomography (OCT). Design: Prospective observational case series. Participants: Twenty-three eyes of 19 patients with corneal opacities referred to a tertiary medical center. Methods: Twenty-three consecutive eyes with corneal opacities were imaged with a high-speed corneal OCT prototype (Carl Zeiss Meditec, Inc., Dublin, CA). The OCT system operates at a speed of 2000 axial scans per second and a wavelength of 1.3 μm. Slit-scanning tomography (Orbscan II, software version 3.12; Bausch & Lomb, Inc., Rochester, NY) and ultrasound pachymetry (Corneo-Gage Plus; Sonogage, Cleveland, OH) also were performed. Main Outcome Measures: Central cornea thickness was measured by the 3 instruments. Results: In eyes with central opacities (n = 17), OCT central cornea thickness measurements were statistically equivalent to ultrasound pachymetry, whereas Orbscan II measurements were significantly less than ultrasound pachymetry (difference, -132.7±143 μm; P = 0.006). The OCT and ultrasound pachymetry results were obtained for all eyes, whereas Orbscan was unable to provide readings in 4 eyes. In eyes with off-center opacities (n = 6), OCT and Orbscan II central cornea thickness measurements were statistically equivalent to ultrasound pachymetry. The OCT measurements of epithelial thickness and scar depth also were demonstrated. Conclusions: Optical coherence tomography provides consistent pachymetry mapping, whereas Orbscan II significantly underestimates corneal thickness in the presence of central corneal scars. Optical coherence tomography could be valuable in the planning of surgical treatment of corneal scars.
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U2 - 10.1016/j.ophtha.2006.10.033
DO - 10.1016/j.ophtha.2006.10.033
M3 - Article
C2 - 17307254
AN - SCOPUS:34347228171
SN - 0161-6420
VL - 114
SP - 1278
EP - 1285
JO - Ophthalmology
JF - Ophthalmology
IS - 7
ER -