Highly efficient one step synthesis of primary amines from B-Chlorodialkylboranes

Sanjay V. Malhotra, Herbert C. Brown

Research output: Contribution to journalArticlepeer-review


A convenient and simple method for synthesis of primary amines has been developed by direct amination of B-Chlorodialkylboranes. This general procedure has been applied to synthesize acyclic, cyclic, hindered and chiral amines in very high yields using both hydroxylamine-O-sulfonic acid and monochloroamine as reagents.

Original languageEnglish (US)
Pages (from-to)383-385
Number of pages3
JournalLetters in Organic Chemistry
Issue number6
StatePublished - Jul 2012
Externally publishedYes


  • Amination
  • B-Chlorodialkylboranes
  • Chiral amine
  • Organoborane

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry


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