TY - JOUR
T1 - Histological and biochemical effects of preventive and therapeutic vascular photobiomodulation on rat muscle injury
AU - Lopez, Talita Christine Camillo
AU - Malavazzi, Tainá Caroline dos Santos
AU - Rodrigues, Maria Fernanda Setúbal Destro
AU - Bach, Erna Elisabeth
AU - Silva, Daniela Teixeira
AU - Hi, Edgar Matias Bach
AU - França, Cristiane Miranda
AU - Bussadori, Sandra Kalil
AU - Mesquita-Ferrari, Raquel Agnelli
AU - Fernandes, Kristianne Porta Santos
N1 - Publisher Copyright:
© 2022 Wiley-VCH GmbH.
PY - 2022/5
Y1 - 2022/5
N2 - The intravascular or transcutaneous application of photobiomodulation (PBM) over blood vessels (vascular photobiomodulation, VPBM) has been used for the treatment of inflammatory and chronic conditions with promising systemic results. This study evaluated the VPBM effects on a model of muscle regeneration after acute injury and compared the outcomes of preventive and therapeutic VPBM. Transcutaneous VPBM was administered over the rat's main tail vein. Serum levels of creatine kinase (CK), aspartate aminotransferase (AST), and lactate were evaluated and muscles were processed for macroscopic and microscopic analysis. Preventive and therapeutic VPBM led to decreased inflammatory infiltrate, edema, and myonecrosis but with an increase in immature muscle fibers. CK, AST, and lactate levels were lower in the groups treated with VPBM (lowest concentrations in preventive VPBM application). Preventive and therapeutic VPBM were capable of exerting a positive effect on acute muscle injury repair, with more accentuated results when preventive VPBM was administered.
AB - The intravascular or transcutaneous application of photobiomodulation (PBM) over blood vessels (vascular photobiomodulation, VPBM) has been used for the treatment of inflammatory and chronic conditions with promising systemic results. This study evaluated the VPBM effects on a model of muscle regeneration after acute injury and compared the outcomes of preventive and therapeutic VPBM. Transcutaneous VPBM was administered over the rat's main tail vein. Serum levels of creatine kinase (CK), aspartate aminotransferase (AST), and lactate were evaluated and muscles were processed for macroscopic and microscopic analysis. Preventive and therapeutic VPBM led to decreased inflammatory infiltrate, edema, and myonecrosis but with an increase in immature muscle fibers. CK, AST, and lactate levels were lower in the groups treated with VPBM (lowest concentrations in preventive VPBM application). Preventive and therapeutic VPBM were capable of exerting a positive effect on acute muscle injury repair, with more accentuated results when preventive VPBM was administered.
KW - NLIB
KW - low-level light therapy
KW - muscle injury
KW - muscle repair
KW - photobiomodulation
KW - vascular photobiomodulation
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U2 - 10.1002/jbio.202100271
DO - 10.1002/jbio.202100271
M3 - Article
C2 - 34978386
AN - SCOPUS:85122870847
SN - 1864-063X
VL - 15
JO - Journal of Biophotonics
JF - Journal of Biophotonics
IS - 5
M1 - e202100271
ER -