Abstract
Introduction: Patients with atopic dermatitis (AD) are uniquely susceptible to a number of serious viral skin complications, including eczema herpeticum (EH), caused by herpes simplex virus. This study explored the associations between biomarkers of epithelial barrier dysfunction, type 2 immunity, Staphylococcus aureus infection, and S. aureus-specific immunoglobulin responses in a cohort of AD subjects with and without a history of EH (EH+ and EH−, respectively). Methods: A total of 112 subjects with AD (56 EH+, 56 EH−), matched by age and AD severity, were selected from a registry of over 3000 AD subjects. Logistic regression was used to test the association between history of S. aureus skin infection and history of EH, while controlling for a number of confounders. Results: Compared to those without a history of S. aureus skin infection, subjects with a history of S. aureus skin infection were found to have more than sixfold increased odds of having a history of EH (6.60, 95% confidence interval [CI]: 2.00–21.83), after adjusting for history of other viral skin infections (molluscum contagiosum virus, human papillomavirus), serum total IgE, and IgG against the S. aureus virulence factor SElX. Conclusions: These findings indicate an important relationship between S. aureus skin infections and EH.
Original language | English (US) |
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Pages (from-to) | 2417-2429 |
Number of pages | 13 |
Journal | Dermatology and Therapy |
Volume | 13 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2023 |
Keywords
- Atopic dermatitis
- Eczema herpeticum
- Immunoglobulins
- S. aureus
- Viral skin infections
ASJC Scopus subject areas
- Dermatology