HLA-B27-associated uveitis: Overview and current perspectives

Eric B. Suhler, Tammy M. Martin, James T. Rosenbaum

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


Purpose of review: To review current knowledge about the pathogenesis, clinical presentation, and treatment of HLA-B27-associated uveitis, which is the most commonly identified cause of uveitis in community-based practice and an important cause of ocular morbidity. Recent findings: Significant advances have been made in understanding the pathogenesis of HLA-B27-associated ocular and systemic disease, especially with regard to the genetic underpinning of these diseases. Increasing attention has also been focused on the use of alternative therapies in the treatment of HLA-B27-associated uveitis, with special attention to sulfa class antibiotics, historically have been used to treat the articular manifestations of the spondyloarthritides, and newer drugs that inhibit tumor necrosis factor-α. Summary: The next several years promise to yield exciting new advances in understanding of the genetic epidemiology and treatment of HLA-B27-associated uveitis.

Original languageEnglish (US)
Pages (from-to)378-383
Number of pages6
JournalCurrent opinion in ophthalmology
Issue number6
StatePublished - Dec 2003


  • Genetics
  • HLA-B27
  • Seronegative spondyloarthropathy
  • Tumor necrosis factor-α
  • Uveitis

ASJC Scopus subject areas

  • Ophthalmology


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