HMGB1-derived peptide acts as adjuvant inducing immune responses to peptide and protein antigen

R. Saenz; C. da Silva Souza; C. T. Huang; M. Larsson; S. Esener; D. Messmer

doi:10.1016/j.vaccine.2010.08.054

HMGB1-derived peptide acts as adjuvant inducing immune responses to peptide and protein antigen

R. Saenz, C. da Silva Souza, C. T. Huang, M. Larsson, S. Esener, D. Messmer

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

There is a need for new adjuvants that will induce immune responses to subunit vaccines. We show that a short peptide, named Hp91, whose sequence corresponds to an area within the endogenous molecule high mobility group box (HMGB1) protein 1 potentiates cellular immune responses to peptide antigen and cellular and humoral immune responses to protein antigen in vivo. Hp91 promoted the in vivo production of the immunomodulatory cytokines, IFN-γ, TNF-α, IL-6, and IL-12 (p70), as well as antigen-specific activation of CD8+ T cells. These results demonstrate the ability of a short immunostimulatory peptide to serve as an adjuvant for subunit vaccines.

Original language	English (US)
Pages (from-to)	7556-7562
Number of pages	7
Journal	Vaccine
Volume	28
Issue number	47
DOIs	https://doi.org/10.1016/j.vaccine.2010.08.054
State	Published - Nov 3 2010
Externally published	Yes

Keywords

Adjuvants
Dendritic cells
HMGB-1 peptides
Immunotherapy
Vaccine

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2010.08.054

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title = "HMGB1-derived peptide acts as adjuvant inducing immune responses to peptide and protein antigen",

abstract = "There is a need for new adjuvants that will induce immune responses to subunit vaccines. We show that a short peptide, named Hp91, whose sequence corresponds to an area within the endogenous molecule high mobility group box (HMGB1) protein 1 potentiates cellular immune responses to peptide antigen and cellular and humoral immune responses to protein antigen in vivo. Hp91 promoted the in vivo production of the immunomodulatory cytokines, IFN-γ, TNF-α, IL-6, and IL-12 (p70), as well as antigen-specific activation of CD8+ T cells. These results demonstrate the ability of a short immunostimulatory peptide to serve as an adjuvant for subunit vaccines.",

keywords = "Adjuvants, Dendritic cells, HMGB-1 peptides, Immunotherapy, Vaccine",

author = "R. Saenz and Souza, {C. da Silva} and Huang, {C. T.} and M. Larsson and S. Esener and D. Messmer",

note = "Funding Information: We would like to thank D. Futalan, D. Seible, J. Steiner, J. Ahlqvist, and N. Ambren for excellent technical assistance. We would like to thank J.F. Fecteau for critical reading of the manuscript. This work is supported by 5 U54 CA119335 from the National Institutes of Health/NCI (to S.E. and D.M.) and the Swedish Research Council AI52731 and the Swedish International Development Cooperation Agency; SIDA and VINNMER (Vinnova) to (ML).",

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AU - Saenz, R.

AU - Souza, C. da Silva

AU - Huang, C. T.

AU - Larsson, M.

AU - Esener, S.

AU - Messmer, D.

N1 - Funding Information: We would like to thank D. Futalan, D. Seible, J. Steiner, J. Ahlqvist, and N. Ambren for excellent technical assistance. We would like to thank J.F. Fecteau for critical reading of the manuscript. This work is supported by 5 U54 CA119335 from the National Institutes of Health/NCI (to S.E. and D.M.) and the Swedish Research Council AI52731 and the Swedish International Development Cooperation Agency; SIDA and VINNMER (Vinnova) to (ML).

PY - 2010/11/3

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N2 - There is a need for new adjuvants that will induce immune responses to subunit vaccines. We show that a short peptide, named Hp91, whose sequence corresponds to an area within the endogenous molecule high mobility group box (HMGB1) protein 1 potentiates cellular immune responses to peptide antigen and cellular and humoral immune responses to protein antigen in vivo. Hp91 promoted the in vivo production of the immunomodulatory cytokines, IFN-γ, TNF-α, IL-6, and IL-12 (p70), as well as antigen-specific activation of CD8+ T cells. These results demonstrate the ability of a short immunostimulatory peptide to serve as an adjuvant for subunit vaccines.

AB - There is a need for new adjuvants that will induce immune responses to subunit vaccines. We show that a short peptide, named Hp91, whose sequence corresponds to an area within the endogenous molecule high mobility group box (HMGB1) protein 1 potentiates cellular immune responses to peptide antigen and cellular and humoral immune responses to protein antigen in vivo. Hp91 promoted the in vivo production of the immunomodulatory cytokines, IFN-γ, TNF-α, IL-6, and IL-12 (p70), as well as antigen-specific activation of CD8+ T cells. These results demonstrate the ability of a short immunostimulatory peptide to serve as an adjuvant for subunit vaccines.

KW - Adjuvants

KW - Dendritic cells

KW - HMGB-1 peptides

KW - Immunotherapy

KW - Vaccine

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JF - Vaccine

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ER -

HMGB1-derived peptide acts as adjuvant inducing immune responses to peptide and protein antigen

Abstract

Keywords

ASJC Scopus subject areas

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