Hormonal responses to the six-minute walk test in women (W) and men (M) with coronary artery disease (CAD)

K. J. Radke, K. B. King, M. L. Blair, P. G. Fitzpatrick, D. H. Eldredge

Research output: Contribution to journalArticlepeer-review


We determined efficacy of the 6-min walk test (exercise) as a stimulus for release of hormones associated with sympathetic activation and fluid/electrolyte regulation in W and M with CAD. Nine W and 9 M with arteriographically-documented CAD and normal LV ejection fractions were matched for age (66 ± 8 yrs) and hypertension; none of the subjects had diabetes mellitus. Maintenance drugs included ACE inhibitors (2W;3M), B-blockers (7W;1M), Ca-channel blockers (1W;2M), diuretics (2W;0M), and nitroglycerin (3W;3M). After venipuncture and 30 min of supine rest, basal blood samples were drawn. Subjects then walked for 6 min to cover as much distance as possible. Post-exercise blood samples were drawn. Basal levels of vasopressin (VP) were significantly higher in M (1.02 ± 0.17 pg/ml) than in W (0.61 ± 0.01 pg/ml). There were no gender differences for basal levels of atrial natriuretic peptide (ANP), plasma renin activity (PRA), norepinephrine (NE), epinephrine (E), cortisol or aldosterone. Exercise for W and M combined significantly increased VP (0.81 ± 0.09 basal to 1.05 ± 0.12 pg/ml post-exercise), ANP (84 ± 20 to 134 ± 25 pg/ml), and NE (240 ± 23 to 448 ± 54 pg/ml) but not PRA (4.40 ± 1.84 to 6.14 ± 2.79 ng/ml/hr) or E (23 ± 1 to 26 ± 2 pg/ml). There were no gender differences for the magnitude of exercise-induced increases for VP, ANP, PRA, NE or E. Conclusions: a gender difference occurred only for basal VP levels; the 6-min walk test is an exercise stressor of sufficient intensity and duration to significantly increase VP, ANP and NE in both W and M with CAD.

Original languageEnglish (US)
Pages (from-to)A1040
JournalFASEB Journal
Issue number5
StatePublished - Mar 20 1998
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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