Hormone Supplementation during aging: How much and when?

K. G. Sorwell, J. Garten, L. Renner, A. Weiss, V. T. Garyfallou, S. G. Kohama, M. Neuringer, H. F. Urbanski

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Circulating levels of dehydroepiandrosterone, a major adrenal steroid, show a marked age-related decrease in both humans and nonhuman primates. Because this decrease has been implicated in age-related cognitive decline, we administered supplementary dehydroepiandrosterone to perimenopausal rhesus macaques (Macaca mulatta) to test for cognitive benefits. Although recognition memory improved, there was no benefit to spatial working memory. To address the limitations of this study we developed a hormone supplementation regimen in aged male macaques that more accurately replicates the 24-hr androgen profiles of young animals. We hypothesize that this more comprehensive physiological hormone replacement paradigm will enhance cognitive function in the elderly.

Original languageEnglish (US)
Pages (from-to)128-131
Number of pages4
JournalRejuvenation Research
Issue number2
StatePublished - Apr 1 2012

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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