How to identify and manage non-response to clozapine?

Mujeeb U. Shad, Emma Felzien, Kamalika Roy, Simrat Sethi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Clozapine is the only approved treatment for Treatment-Refractory Schizophrenia. Here we describe a case series of three hospitalized patients with clozapine nonresponse. One of them responded to clozapine after dose adjustments were made for an interaction between clozapine and ciprofloxacin. The other two cases remained clozapine nonresponders despite optimizing clozapine treatment. However, both these patients responded to other antipsychotic medications (APMs) with better tolerability than observed with clozapine treatment. This case series focuses on diagnosing a genuine from a pseudo-nonresponse to clozapine and to consider other APMs in genuine nonresponse before switching to invasive interventions, such as ECT.

Original languageEnglish (US)
Pages (from-to)50-52
Number of pages3
JournalAsian Journal of Psychiatry
StatePublished - Oct 2019


  • Clozapine
  • Identify
  • Manage
  • Non-response

ASJC Scopus subject areas

  • General Psychology
  • Psychiatry and Mental health


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