Abstract
Neurological disease frequently complicates HIV-1 infection. In addition to opportunistic infections, a syndrome of combined cognitive and motor impairment, referred to as the AIDS dementia complex, has been recognized. While presumed to relate to HIV-1 itself, the pathogenesis of this syndrome remains uncertain. Because of the limited extent of productive brain HIV-I infection in many cases, and because such infection involves macrophages and microglia rather than cells of neuroectodermal origin, current speculation centers on indirect mechanisms of brain injury including virus- or cell-coded neurotoxins. We review clinical and laboratory studies and also describe models of the interaction of HIV-1 and immune responses that might account for brain injury.
Original language | English (US) |
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Pages (from-to) | 655-693 |
Number of pages | 39 |
Journal | Annual Review of Microbiology |
Volume | 46 |
DOIs | |
State | Published - 1992 |
Externally published | Yes |
Keywords
- AIDS
- AIDS dementia complex
- brain retroviruses
- dementia
ASJC Scopus subject areas
- Microbiology