Hydroxy-anthraquinones as antimalarial agents

R. W. Winter, Kenneth A. Cornell, Linda L. Johnson, Loren M. Isabelle, David J. Hinrichs, Michael K. Riscoe

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


A series of hydroxy- and polyhydroxy-anthraquinones were screened for inhibitory activity against the malarial parasite, Plasmodium falciparum. Rufigallol demonstrated the most potent effects with a 50% inhibitory concentration (IC50 value of ∼10.5 ng/ml (∼35 nM). Deleterious effects were exerted by rufigallol toward bone marrow progenitor cells at concentrations≥ 10 μM (3 μg/ml) where ∼30% suppression of colony growth was noted. Taking into consideration its potency and relative lack of toxicity, we believe that rufigallol should be advanced for in vivo studies. At the very least, rufigallol represents a simple, inexpensive lead drug for the development of more potent analogs.

Original languageEnglish (US)
Pages (from-to)1927-1932
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number17
StatePublished - Sep 7 1995

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


Dive into the research topics of 'Hydroxy-anthraquinones as antimalarial agents'. Together they form a unique fingerprint.

Cite this