Hypertensive disease of pregnancy and maternal mortality

Jamie O. Lo, John F. Mission, Aaron B. Caughey

Research output: Contribution to journalReview articlepeer-review

279 Scopus citations


Purpose of Review: The incidence of hypertensive disorders in pregnancy is increasing and is associated with maternal mortality worldwide. This review provides the obstetrician with an update of the current issues concerning hypertension and maternal mortality. Recent Findings: Preeclampsia affects about 3% of pregnancies, and all other hypertensive disorders complicate approximately 5-10% of pregnancies in the United States. In industrialized countries, rates of preeclampsia, gestational hypertension, and chronic hypertension have increased as rates of eclampsia have decreased following widespread antenatal care and magnesium sulfate use. Increased maternal mortality is associated with eclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome, hepatic or central nervous system hemorrhage, and vascular insult to the cardiopulmonary or renal system. Diagnosis and acute management of severe hypertension is central to reducing maternal mortality. African-American women have a higher risk of mortality from hypertensive disorders of pregnancy compared with Hispanic, American Indian/Alaska Native, Asian/Pacific Islander, and Caucasian women. Summary: Hypertensive disorders in pregnancy are a leading cause of maternal mortality worldwide. The incidence of hypertension in pregnancy continues to increase. Currently, we are unable to determine which patient will develop superimposed preeclampsia or identify subsets of preeclampsia syndrome. Opportunities for research in this area exist to better define treatment aimed at improving maternal outcomes.

Original languageEnglish (US)
Pages (from-to)124-132
Number of pages9
JournalCurrent Opinion in Obstetrics and Gynecology
Issue number2
StatePublished - Apr 2013


  • hypertension
  • mortality
  • preeclampsia
  • pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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