Abstract
Objective: Women who develop pre-eclampsia show significantly less hypervolemia of pregnancy, compared with controls. We have shown that chronically elevated angiotensinogen expression increases a woman's risk of developing pre-eclampsia. Our objective was to determine whether increased angiotensinogen expression is sufficient to cause failed hypervolemia. Study design: To isolate the effects of elevated angiotensinogen expression, we studied transgenic mice with either 2 or 3 copies of the murine angiotensinogen gene. Plasma volume was measured by Evans blue dye dilution, and kidney sections were immunostained for angiotensinogen and renin. Results: Three-copy mice failed to maintain hypervolemia after midgestation (P < .01) and failed to up-regulate renin expression in the distal nephron, compared with 2-copy controls. Intrarenal angiotensinogen was up-regulated during pregnancy in both genotypes. Conclusion: Chronically elevated angiotensinogen expression is sufficient to cause failed hypervolemia of pregnancy. Whether this observation is related to failed up-regulation of distal tubule renin expression requires further study.
Original language | English (US) |
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Pages (from-to) | 1700-1706 |
Number of pages | 7 |
Journal | American journal of obstetrics and gynecology |
Volume | 195 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2006 |
Externally published | Yes |
Keywords
- Intrarenal renin-angiotensin system
- Kidney
- Mouse
- Plasma volume
- Pregnancy
ASJC Scopus subject areas
- Obstetrics and Gynecology