Hyphal forms in the central nervous system of patients with coccidioidomycosis

Heidi M. Hagman; Ellen G. Madnick; Anthony N. D'Agostino; Paul L. Williams; Stanley Shatsky; Laurence F. Mirels; Richard M. Tucker; Michael G. Rinaldi; David A. Stevens; Richard E. Bryant

doi:10.1086/313643

Hyphal forms in the central nervous system of patients with coccidioidomycosis

Heidi M. Hagman, Ellen G. Madnick, Anthony N. D'Agostino, Paul L. Williams, Stanley Shatsky, Laurence F. Mirels, Richard M. Tucker, Michael G. Rinaldi, David A. Stevens, Richard E. Bryant

Infectious Diseases

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Coccidioides immitis is a dimorphic fungus that grows as a filamentous mold in soil and as a spherule at human body temperature. The hyphal or soil form is found rarely in human tissue. We report 5 cases of coccidioidomycosis in which hyphae were found in brain tissue or spinal fluid. The presence of central nervous system plastic devices appears to be associated with morphological reversion to the saprophytic form. This reversion has implications for diagnosis and therapy and may increase the risk of obstruction of the device(s).

Original language	English (US)
Pages (from-to)	349-355
Number of pages	7
Journal	Clinical Infectious Diseases
Volume	30
Issue number	2
DOIs	https://doi.org/10.1086/313643
State	Published - 2000

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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title = "Hyphal forms in the central nervous system of patients with coccidioidomycosis",

abstract = "Coccidioides immitis is a dimorphic fungus that grows as a filamentous mold in soil and as a spherule at human body temperature. The hyphal or soil form is found rarely in human tissue. We report 5 cases of coccidioidomycosis in which hyphae were found in brain tissue or spinal fluid. The presence of central nervous system plastic devices appears to be associated with morphological reversion to the saprophytic form. This reversion has implications for diagnosis and therapy and may increase the risk of obstruction of the device(s).",

author = "Hagman, {Heidi M.} and Madnick, {Ellen G.} and D'Agostino, {Anthony N.} and Williams, {Paul L.} and Stanley Shatsky and Mirels, {Laurence F.} and Tucker, {Richard M.} and Rinaldi, {Michael G.} and Stevens, {David A.} and Bryant, {Richard E.}",

year = "2000",

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T1 - Hyphal forms in the central nervous system of patients with coccidioidomycosis

AU - Hagman, Heidi M.

AU - Madnick, Ellen G.

AU - D'Agostino, Anthony N.

AU - Williams, Paul L.

AU - Shatsky, Stanley

AU - Mirels, Laurence F.

AU - Tucker, Richard M.

AU - Rinaldi, Michael G.

AU - Stevens, David A.

AU - Bryant, Richard E.

PY - 2000

Y1 - 2000

N2 - Coccidioides immitis is a dimorphic fungus that grows as a filamentous mold in soil and as a spherule at human body temperature. The hyphal or soil form is found rarely in human tissue. We report 5 cases of coccidioidomycosis in which hyphae were found in brain tissue or spinal fluid. The presence of central nervous system plastic devices appears to be associated with morphological reversion to the saprophytic form. This reversion has implications for diagnosis and therapy and may increase the risk of obstruction of the device(s).

AB - Coccidioides immitis is a dimorphic fungus that grows as a filamentous mold in soil and as a spherule at human body temperature. The hyphal or soil form is found rarely in human tissue. We report 5 cases of coccidioidomycosis in which hyphae were found in brain tissue or spinal fluid. The presence of central nervous system plastic devices appears to be associated with morphological reversion to the saprophytic form. This reversion has implications for diagnosis and therapy and may increase the risk of obstruction of the device(s).

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Hyphal forms in the central nervous system of patients with coccidioidomycosis

Abstract

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