@article{51da2a93a90a4061bb1aa31f009bd1b8,
title = "Iatrogenic choroidal neovascularization associated with subretinal gene therapy surgery",
abstract = "Purpose: To report a case of iatrogenic choroidal neovascularization (CNV) developing one month after subretinal gene therapy surgery. Observations: A 16-year-old male with biallelic RPE65 mutation associated retinal dystrophy was treated with subretinal voretigene neparvovec in the left eye. During initiation of a balanced salt solution pre-bleb, a faint and transient subretinal hemorrhage was observed at the retinotomy site. One month post-operatively, multi-modal imaging detected a CNV and a break in Bruch's membrane at the retinotomy site. The asymptomatic CNV was observed without treatment and resolved spontaneously. Conclusions & importance: As subretinal gene therapy surgery becomes more common, clinicians should monitor for possible trauma induced CNV associated with retinotomy formation and subretinal injection.",
keywords = "Macular surgery, Subretinal gene therapy, Traumatic choroidal neovascularization",
author = "Price, {Kenneth W.} and Pennesi, {Mark E.} and Lauer, {Andreas K.} and Bailey, {Steven T.}",
note = "Funding Information: P30 EY010572 from the National Institutes of Health (Bethesda, MD), and by unrestricted departmental funding from Research to Prevent Blindness (New York, NY). Funding Information: P30 EY010572 from the National Institutes of Health (Bethesda, MD), and by unrestricted departmental funding from Research to Prevent Blindness (New York, NY).Andreas Lauer discloses the following: Applied Genetic Technologies Corporation (Consultant, Co-investigator), Atsena (Consultant, Co-investigator), California Institute or Regenerative Medicine (Co-investigator), Biogen (Consultant, Co-investigator), Editas (Co-investigator), Genentech (Research support - Principal Investigator), Ivericbio (Consultant, Co-investigator), Johnson & Johnson (Consultant), Oxford BioMedica (Research support - Principal Investigator), REGENXBIO (Consultant), and Sanofi (Co-investigator). Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = sep,
doi = "10.1016/j.ajoc.2022.101677",
language = "English (US)",
volume = "27",
journal = "American Journal of Ophthalmology Case Reports",
issn = "2451-9936",
publisher = "Elsevier Inc.",
}