Identification of insulin-uke growth factor-binding protein-2 (IGF-BP-2) and a low molecular weight igf-bp in human seminal plasma

Ron G. Rosenfeld; Hung Pham; Youngman Oh; George Lamson; Linda C. Giudice

doi:10.1210/jcem-70-2-551

Identification of insulin-uke growth factor-binding protein-2 (IGF-BP-2) and a low molecular weight igf-bp in human seminal plasma

Ron G. Rosenfeld, Hung Pham, Youngman Oh, George Lamson, Linda C. Giudice

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Three distinct binding proteins for the insulin-like growth factors (IGF-BPs) have recently had their cDNAs cloned and sequenced. We have evaluated IGF-BP expression in normal, oligospermic and azospermic human seminal plasma (SP), and have identified IGF-BP-2 in all samples. Additionally, SP contains a non-glycosylated low molecular weight IGF-BP (24K), which does not appear to be structurally or immunologically related to IGF-BP-1, -2 or -3.

Original language	English (US)
Pages (from-to)	551-553
Number of pages	3
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	70
Issue number	2
DOIs	https://doi.org/10.1210/jcem-70-2-551
State	Published - Feb 1990
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1210/jcem-70-2-551

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AU - Rosenfeld, Ron G.

AU - Pham, Hung

AU - Oh, Youngman

AU - Lamson, George

AU - Giudice, Linda C.

PY - 1990/2

Y1 - 1990/2

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AB - Three distinct binding proteins for the insulin-like growth factors (IGF-BPs) have recently had their cDNAs cloned and sequenced. We have evaluated IGF-BP expression in normal, oligospermic and azospermic human seminal plasma (SP), and have identified IGF-BP-2 in all samples. Additionally, SP contains a non-glycosylated low molecular weight IGF-BP (24K), which does not appear to be structurally or immunologically related to IGF-BP-1, -2 or -3.

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Identification of insulin-uke growth factor-binding protein-2 (IGF-BP-2) and a low molecular weight igf-bp in human seminal plasma

Abstract

ASJC Scopus subject areas

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