Identification of novel simian endogenous retroviruses that are indistinguishable from simian retrovirus (SRV) on current SRV diagnostic assays

Richard Grant; Brandon Keele; La Rene Kuller; Robin Watanabe; Alex Perret; Jeremy Smedley

doi:10.1111/jmp.12297

Identification of novel simian endogenous retroviruses that are indistinguishable from simian retrovirus (SRV) on current SRV diagnostic assays

Richard Grant, Brandon Keele, La Rene Kuller, Robin Watanabe, Alex Perret, Jeremy Smedley

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Simian betaretroviruses include the well-known exogenous simian retroviruses (SRV-1 through SRV-8), and some closely related simian endogenous retroviruses (SERV). Here, we characterized two new viral genomes, which appear to represent novel SERVs but have characteristics of both SRV and SERV highlighting the need to develop new assays providing molecular and serologic differentiation of SERV and SRV to avoid false positives.

Original language	English (US)
Pages (from-to)	158-161
Number of pages	4
Journal	Journal of medical primatology
Volume	46
Issue number	4
DOIs	https://doi.org/10.1111/jmp.12297
State	Published - Aug 2017
Externally published	Yes

Keywords

Macaque
PCR
Specific Pathogen-Free (SPF)
sequencing
western blot

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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10.1111/jmp.12297

Cite this

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title = "Identification of novel simian endogenous retroviruses that are indistinguishable from simian retrovirus (SRV) on current SRV diagnostic assays",

abstract = "Simian betaretroviruses include the well-known exogenous simian retroviruses (SRV-1 through SRV-8), and some closely related simian endogenous retroviruses (SERV). Here, we characterized two new viral genomes, which appear to represent novel SERVs but have characteristics of both SRV and SERV highlighting the need to develop new assays providing molecular and serologic differentiation of SERV and SRV to avoid false positives.",

keywords = "Macaque, PCR, Specific Pathogen-Free (SPF), sequencing, western blot",

author = "Richard Grant and Brandon Keele and Kuller, {La Rene} and Robin Watanabe and Alex Perret and Jeremy Smedley",

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T1 - Identification of novel simian endogenous retroviruses that are indistinguishable from simian retrovirus (SRV) on current SRV diagnostic assays

AU - Grant, Richard

AU - Keele, Brandon

AU - Kuller, La Rene

AU - Watanabe, Robin

AU - Perret, Alex

AU - Smedley, Jeremy

N1 - Funding Information: We thank the animal care and scientific support staff at Washington National Primate Research Centers for providing excellent technical support for this study. This work was supported by NIH grants WANPRC P51OD010425. Publisher Copyright: © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

PY - 2017/8

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N2 - Simian betaretroviruses include the well-known exogenous simian retroviruses (SRV-1 through SRV-8), and some closely related simian endogenous retroviruses (SERV). Here, we characterized two new viral genomes, which appear to represent novel SERVs but have characteristics of both SRV and SERV highlighting the need to develop new assays providing molecular and serologic differentiation of SERV and SRV to avoid false positives.

AB - Simian betaretroviruses include the well-known exogenous simian retroviruses (SRV-1 through SRV-8), and some closely related simian endogenous retroviruses (SERV). Here, we characterized two new viral genomes, which appear to represent novel SERVs but have characteristics of both SRV and SERV highlighting the need to develop new assays providing molecular and serologic differentiation of SERV and SRV to avoid false positives.

KW - Macaque

KW - PCR

KW - Specific Pathogen-Free (SPF)

KW - sequencing

KW - western blot

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Identification of novel simian endogenous retroviruses that are indistinguishable from simian retrovirus (SRV) on current SRV diagnostic assays

Abstract

Keywords

ASJC Scopus subject areas

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