Abstract
The involvement of the TP53 tumor suppressor gene in uterine corpus cancer was investigated by single-stranded conformation polymorphism and sequence analysis of its exons 4 to 10. Mutations were found in 12 (18.5%) of 65 cases. Ten of these 12 were single-base substitutions (8 missense and 2 nonsense mutations), whereas 2 were frame-shifting mutations. TP53 gene mutations correlated significantly with advanced surgical stage of disease (P = 0.006) and unfavorable tumor histology types (P = 0.003), whereas the association to myometrial wall invasion did not reach statistical significance (P = 0.054). TP53 gene mutations also correlated significantly with allelic loss at TP53 locus (P = 0.024), absence of estrogen (P = 0.045) and progesterone receptors (P = 0.001), DNA nondiploidy (P = 0.002), and high S-phase fraction values (P = 0.002). Our results suggest that inactivation of the TP53 checkpoint function is associated with disease transition into a stage of rapid progression and spread.
Original language | English (US) |
---|---|
Pages (from-to) | 295-302 |
Number of pages | 8 |
Journal | Gynecologic oncology |
Volume | 67 |
Issue number | 3 |
DOIs | |
State | Published - Dec 1997 |
Externally published | Yes |
Keywords
- DNA ploidy
- Mutation
- TP53
- Uterine corpus cancer
ASJC Scopus subject areas
- Oncology
- Obstetrics and Gynecology