IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice

Jun Zhang; Gil Benedek; Sheetal Bodhankar; Andrew Lapato; Arthur A. Vandenbark; Halina Offner

doi:10.1016/j.jneuroim.2015.06.002

IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice

Jun Zhang, Gil Benedek, Sheetal Bodhankar, Andrew Lapato, Arthur A. Vandenbark, Halina Offner

Neurology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Women with multiple sclerosis (MS) often experience clinical improvement during pregnancy, indicating that sex hormones might have therapeutic effects in MS. Our previous studies have demonstrated that B cells and PD-L1 are crucial for E2 (17β-estradiol)-mediated protection against experimental autoimmune encephalomyelitis (EAE). We here demonstrate that the transfer of IL-10⁺ B cells into E2-treated PD-L1^-/- mice after EAE induction could partially restore E2-mediated protection and decrease the frequency of pro-inflammatory cells in the CNS compared to E2/saline treated PD-L1^-/- mice. Hence, co-administration of IL-10⁺ B cells and E2 might have a powerful therapeutic potential for treatment of EAE.

Original language	English (US)
Pages (from-to)	129-136
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	285
DOIs	https://doi.org/10.1016/j.jneuroim.2015.06.002
State	Published - 2015

Keywords

EAE
Estrogen
IL-10
PD-L1
PD-L2
Regulatory B cell

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2015.06.002

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title = "IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice",

abstract = "Women with multiple sclerosis (MS) often experience clinical improvement during pregnancy, indicating that sex hormones might have therapeutic effects in MS. Our previous studies have demonstrated that B cells and PD-L1 are crucial for E2 (17β-estradiol)-mediated protection against experimental autoimmune encephalomyelitis (EAE). We here demonstrate that the transfer of IL-10+ B cells into E2-treated PD-L1-/- mice after EAE induction could partially restore E2-mediated protection and decrease the frequency of pro-inflammatory cells in the CNS compared to E2/saline treated PD-L1-/- mice. Hence, co-administration of IL-10+ B cells and E2 might have a powerful therapeutic potential for treatment of EAE.",

keywords = "EAE, Estrogen, IL-10, PD-L1, PD-L2, Regulatory B cell",

author = "Jun Zhang and Gil Benedek and Sheetal Bodhankar and Andrew Lapato and Vandenbark, {Arthur A.} and Halina Offner",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

doi = "10.1016/j.jneuroim.2015.06.002",

language = "English (US)",

volume = "285",

pages = "129--136",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

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TY - JOUR

T1 - IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice

AU - Zhang, Jun

AU - Benedek, Gil

AU - Bodhankar, Sheetal

AU - Lapato, Andrew

AU - Vandenbark, Arthur A.

AU - Offner, Halina

PY - 2015

Y1 - 2015

N2 - Women with multiple sclerosis (MS) often experience clinical improvement during pregnancy, indicating that sex hormones might have therapeutic effects in MS. Our previous studies have demonstrated that B cells and PD-L1 are crucial for E2 (17β-estradiol)-mediated protection against experimental autoimmune encephalomyelitis (EAE). We here demonstrate that the transfer of IL-10+ B cells into E2-treated PD-L1-/- mice after EAE induction could partially restore E2-mediated protection and decrease the frequency of pro-inflammatory cells in the CNS compared to E2/saline treated PD-L1-/- mice. Hence, co-administration of IL-10+ B cells and E2 might have a powerful therapeutic potential for treatment of EAE.

AB - Women with multiple sclerosis (MS) often experience clinical improvement during pregnancy, indicating that sex hormones might have therapeutic effects in MS. Our previous studies have demonstrated that B cells and PD-L1 are crucial for E2 (17β-estradiol)-mediated protection against experimental autoimmune encephalomyelitis (EAE). We here demonstrate that the transfer of IL-10+ B cells into E2-treated PD-L1-/- mice after EAE induction could partially restore E2-mediated protection and decrease the frequency of pro-inflammatory cells in the CNS compared to E2/saline treated PD-L1-/- mice. Hence, co-administration of IL-10+ B cells and E2 might have a powerful therapeutic potential for treatment of EAE.

KW - EAE

KW - Estrogen

KW - IL-10

KW - PD-L1

KW - PD-L2

KW - Regulatory B cell

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DO - 10.1016/j.jneuroim.2015.06.002

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AN - SCOPUS:84943238410

SN - 0165-5728

VL - 285

SP - 129

EP - 136

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice

Abstract

Keywords

ASJC Scopus subject areas

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