Imidazolium-derived ionic salts induce inhibition of cancerous cell growth through apoptosis

Sanjay V. Malhotra; Vineet Kumar; Christian Velez; Beatriz Zayas

doi:10.1039/c4md00161c

Imidazolium-derived ionic salts induce inhibition of cancerous cell growth through apoptosis

Sanjay V. Malhotra, Vineet Kumar, Christian Velez, Beatriz Zayas

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

A study of the effects of imidazolium-based ionic liquids on 60 human cancer cell lines representing diverse histologies has identified four compounds which show potency at a nanomolar dose. Their effects on annexin V, DNA fragmentation, and the cell cycle, together with mitochondrial membrane permeabilization tests, provide insights into their mechanism of action. Also, experiments with A431 human epidermoid carcinoma cells suggest the activation of an apoptotic pathway, due to activity of the initiator caspase 8 and effector caspase 3.

Original language	English (US)
Pages (from-to)	1404-1409
Number of pages	6
Journal	MedChemComm
Volume	5
Issue number	9
DOIs	https://doi.org/10.1039/c4md00161c
State	Published - Sep 2014
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

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10.1039/c4md00161c

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abstract = "A study of the effects of imidazolium-based ionic liquids on 60 human cancer cell lines representing diverse histologies has identified four compounds which show potency at a nanomolar dose. Their effects on annexin V, DNA fragmentation, and the cell cycle, together with mitochondrial membrane permeabilization tests, provide insights into their mechanism of action. Also, experiments with A431 human epidermoid carcinoma cells suggest the activation of an apoptotic pathway, due to activity of the initiator caspase 8 and effector caspase 3.",

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AU - Velez, Christian

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AB - A study of the effects of imidazolium-based ionic liquids on 60 human cancer cell lines representing diverse histologies has identified four compounds which show potency at a nanomolar dose. Their effects on annexin V, DNA fragmentation, and the cell cycle, together with mitochondrial membrane permeabilization tests, provide insights into their mechanism of action. Also, experiments with A431 human epidermoid carcinoma cells suggest the activation of an apoptotic pathway, due to activity of the initiator caspase 8 and effector caspase 3.

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Imidazolium-derived ionic salts induce inhibition of cancerous cell growth through apoptosis

Abstract

ASJC Scopus subject areas

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