TY - JOUR
T1 - Immunologic considerations for generating memory CD8 T cells through vaccination
AU - Butler, Noah S.
AU - Nolz, Jeffrey C.
AU - Harty, John T.
PY - 2011/7
Y1 - 2011/7
N2 - Following infection or vaccination, naïve CD8 T cells that receive the appropriate integration of antigenic, co-stimulatory and inflammatory signals undergo a programmed series of biological changes that ultimately results in the generation of memory cells. Memory CD8 T cells, in contrast to naïve cells, more effectively limit or prevent pathogen re-infection because of both qualitative and quantitative changes that occur following their induction. Unlike vaccination strategies aimed at generating antibody production, the ability to generate protective memory CD8 T cells has proven more complicated and problematic. However, recent experimental results have revealed important principles regarding the molecular and genetic basis for memory CD8 T cell formation, as well as identified ways to manipulate their development through vaccination, resulting in potential new avenues to enhance protective immunity.
AB - Following infection or vaccination, naïve CD8 T cells that receive the appropriate integration of antigenic, co-stimulatory and inflammatory signals undergo a programmed series of biological changes that ultimately results in the generation of memory cells. Memory CD8 T cells, in contrast to naïve cells, more effectively limit or prevent pathogen re-infection because of both qualitative and quantitative changes that occur following their induction. Unlike vaccination strategies aimed at generating antibody production, the ability to generate protective memory CD8 T cells has proven more complicated and problematic. However, recent experimental results have revealed important principles regarding the molecular and genetic basis for memory CD8 T cell formation, as well as identified ways to manipulate their development through vaccination, resulting in potential new avenues to enhance protective immunity.
UR - http://www.scopus.com/inward/record.url?scp=79959198170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959198170&partnerID=8YFLogxK
U2 - 10.1111/j.1462-5822.2011.01594.x
DO - 10.1111/j.1462-5822.2011.01594.x
M3 - Short survey
C2 - 21501363
AN - SCOPUS:79959198170
SN - 1462-5814
VL - 13
SP - 925
EP - 933
JO - Cellular Microbiology
JF - Cellular Microbiology
IS - 7
ER -